Glia-to-neuron reprogramming to the rescue?  

作　　者：Jack W.Hickmott Cindi M.Morshead 

机构地区：[1]Department of Surgery,University of Toronto,Toronto,ON,Canada [2]Donnelly Centre for Cellular and Biomolecular Research,Toronto,ON,Canada [3]Institute of Biomedical Engineering,University of Toronto,Toronto,ON,Canada [4]The KITE Research Institute,Toronto Rehabilitation Institute,University Health Network,Toronto,ON,Canada

出　　处：《Neural Regeneration Research》2025年第5期1395-1396,共2页中国神经再生研究（英文版）

基　　金：supported by Canada First Research Excellence Fund,Medicine by Design(to CMM)。

摘　　要：Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative medicine.The brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be changed.An exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.

关 键 词：programming PASSING proof 

分 类 号：R338[医药卫生—人体生理学]