持续性高过载下人脑的多孔弹性响应  

Poroelastic Responses of Human Brain Under Sustained High Overloads

作　　者：田金 刘少宝 卢天健 徐峰[2,3] TIAN Jin;LIU Shaobao;LU Tianjian;XU Feng(The Second Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,P.R.China;Key Laboratory of Biomedical Information Engineering of Ministry of Education,School of Life Science and Technology,Xi’an Jiaotong University,Xi’an 710049,P.R.China;Bioinspired Engineering and Biomechanics Center(BEBC),Xi’an Jiaotong University,Xi’an 710049,P.R.China;State Key Laboratory of Mechanics and Control for Aerospace Structures,Nanjing University of Aeronautics and Astronautics,Nanjing 210016,P.R.China;MIIT Key Laboratory of Multifunctional Lightweight Materials and Structures,Nanjing University of Aeronautics and Astronautics,Nanjing 210016,P.R.China)

机构地区：[1]西安交通大学第二附属医院,西安710061 [2]西安交通大学生命科学与技术学院生物医学信息工程教育部重点实验室,西安710049 [3]西安交通大学仿生工程与生物力学研究所,西安710049 [4]南京航空航天大学航空航天结构力学及控制全国重点实验室,南京210016 [5]南京航空航天大学多功能轻量化材料与结构工信部重点实验室,南京210016

出　　处：《应用数学和力学》2024年第6期691-709,共19页Applied Mathematics and Mechanics

摘　　要：航空航天飞行期间经常出现的持续性高过载,对乘员的脑功能有重要影响,而脑功能受脑组织力学行为的影响,且后者与载荷特点高度相关.为预测持续性高过载下的人脑力学响应,该文采用多孔弹性本构描述了脑组织的力学行为,基于简化的头部一维多层结构模型,推导了脑组织的多孔弹性控制方程、状态量传递矩阵,利用La-place变换及其逆变换,得到了颅内液体压力、颅内液体渗流速度、脑组织有效应力、脑组织位移的时空分布.结果表明,颅内液体渗流对脑组织在持续性高过荷下的响应有显著影响.该文强调采用多孔弹性本构描述脑组织力学行为的适切性和必要性,为极端载荷条件下人脑生物力学响应研究提供了重要的理论见解.Sustained high overloads often acting during aerospace flights can significantly affect the passenger brain function dependent on the mechanical behavior of brain tissue and highly correlated with load characteris-tics.To predict the mechanical responses of human brain under sustained high overloads,the poroelastic con-stitutive model was adopted to characterize the mechanical behaviors of brain tissue.Built on an idealized 1D multi-layer structural model for human heads,the poroelastic control equation and the state transfer matrix for the brain tissue were derived.Through the Laplace transform and its inverse transform,the spatiotemporal dis-tribution of the intracranial fluid pressure,the intracranial fluid seepage velocity,the brain tissue effective stress,and the brain tissue displacement were obtained.The results indicate that,the intracranial fluid infiltra-tion has a significant impact on the responses of the brain tissue under sustained high overloads.The present work emphasizes the appropriateness and necessity of using poroelastic constitutive models to describe the me-chanical behavior of brain tissue,providing important theoretical insights for the study of brain biomechanics under extreme load conditions.

关 键 词：脑组织力学响应 持续性高过载 多孔弹性本构 

分 类 号：O34[理学—固体力学]