Hippo信号通路效应分子在风湿免疫系统疾病中的作用研究进展  

Research progress on Hippo signaling pathway effector molecules in rheumatic immune system diseases

作　　者：高洁 皮彩虹 潘俊梅 周玮[1,2] GAO Jie;PI Caihong;PAN Junmei;ZHOU Wei(Department of Rheumatology and Immunology,Affiliated Hospital of Yangzhou University,Yangzhou 225003,Jiangsu Province,China;Graduate School of Dalian Medical University,Dalian 116044,Liaoning Province,China)

机构地区：[1]扬州大学附属医院风湿免疫科,江苏扬州225003 [2]大连医科大学研究生院,辽宁大连116044

出　　处：《浙江大学学报（医学版）》2024年第3期376-381,共6页Journal of Zhejiang University(Medical Sciences)

基　　金：国家自然科学基金(82101890);江苏省自然科学基金(BK20190904)。

摘　　要：Hippo信号通路的核心组分包括上游调控分子、核心激酶级联复合体和下游转录调控复合体,其通过调控核心成分的效应分子影响细胞生物学行为,在免疫调节中发挥重要作用。这些效应分子主要有Yes相关蛋白(YAP)、转录共激活因子PDZ结合基序(TAZ)、转录增强结构域转录因子(TEAD)、单极纺锤体结合蛋白1(MOB1)、大肿瘤抑制激酶(LATS)等,具有促进类风湿关节炎成纤维细胞样滑膜细胞迁移和侵袭、调控骨关节炎疾病进程、促进病理性新骨形成推动强直性脊柱炎进展、维持颌下腺发育延缓干燥综合征疾病进程、介导α-平滑肌肌动蛋白影响系统性硬化病、介导相关靶基因调控肺纤维化等作用。本文综述了Hippo通路相关效应分子在风湿免疫系统疾病发生和进展中的调控机制,以期为探讨风湿免疫系统疾病临床治疗新靶标提供参考。The core components of the Hippo signaling pathway encompass upstream regulatory molecules,core kinase cascade complexes,and downstream transcriptional regulation complexes.This pathway modulates cellular behaviors by influencing the effector molecules of its core components and plays a pivotal role in immune regulation.Effector molecules,such as Yes-associated protein(YAP),transcriptional coactivator with PDZbinding motif(TAZ),transcriptional enhanced associate domain transcriptional factor(TEAD),monopolar spindle-one binder(MOB1),large tumor suppressor(LATS),can stimulate fibroblast-like synovial cell migration and invasion in rheumatoid arthritis,regulate osteoarthritis disease progression,promote pathological new bone formation in ankylosing spondylitis,sustain submandibular gland development while delaying Sjogren’s syndrome progression,mediate alpha-smooth muscle actin in systemic sclerosis,and refine the regulation of target genes associated with pulmonary fibrosis.This article provides an overview of the regulatory mechanisms involving Hippo signaling pathwayrelated effector molecules in the pathogenesis and progression of rheumatic immune system diseases,to serve as a reference for exploring novel therapeutic targets of rheumatic immune system diseases.

关 键 词：Hippo信号通路 风湿病 发病机制 综述 

分 类 号：R593[医药卫生—内科学]