基于CO_(2)促进传输的抗凝血非对称PMP膜的构建及其性能研究  

Construction and properties research of anticoagulated asymmetric PMP membrane based on CO_(2) facilitated transport

作　　者：田懿 朱怡学 童霄 王敏洁 贾桂玲 陈大竞 黄小军[1] TIAN Yi;ZHU Yixue;TONG Xiao;WANG Minjie;JIA Guiling;CHEN Dajing;HUANG Xiaojun(Zhejiang University,Department of Polymer Science and Engineering,Hangzhou 310027,China;Hangzhou Normal University,School of Pharmacy,Faculty of Medicine,Hangzhou 311121,China;.3.Challenge IM(Beijing)Technology Co.,Ltd,Beijing 102600,China)

机构地区：[1]浙江大学高分子科学与工程学系,杭州310027 [2]杭州师范大学医学部药学院,杭州311121 [3]成器智造(北京)科技有限公司,北京102600

出　　处：《膜科学与技术》2024年第3期38-48,共11页Membrane Science and Technology

基　　金：国家自然科学基金资助项目(22075242,52103271);国家自然科学基金区域创新重点项目(U21A20300)。

摘　　要：新冠疫情期间,为重症患者的心肺功能提供短暂支持的ECMO仪器对人类尤为重要,但其核心组件氧合膜材料被3M公司全球垄断.PMP(聚-4-甲基-1-戊烯)由于具有较为优异的气体渗透能力和生物相容性,在氧合器膜材料中有着巨大的潜力.本文通过TIPs法制备PMP中空纤维膜,并以此作为基材通过静电作用力驱动的层层自组装在表面引入PEI和肝素组成的正负电荷改性层,制备了具有非对称结构的PMP复合膜并研究了改性条件对复合膜表面结构组成和气体传输、血液相容性等性能的影响.结果表明,通过层层自组装引入的PEI-肝素改性层极大地提高了PMP中空纤维复合膜的气体传输性能和血液相容性,使其在气体分离、膜式氧合等领域具有了重要的应用潜力.In the COVID-19 epidemic era,ECMO(Extracorporeal Membrane Oxygenation),which provides temporary support for the cardiopulmonary function of critically ill patients,is particularly important for humans.However,the core component of ECMO,oxygenated membrane material,has been monopolized by 3M company.Therefore,it is of great significance to realize the localization of oxygenated membrane.PMP(poly-4-methyl-1-pentene)has great potential in oxygenated membrane materials due to its excellent gas permeability and biocompatibility.Here we used PMP hollow fiber membrane prepared by TIPs(Thermally Induced Phase separation)as the substrate,and then introduced the positive and negative charge modification layers composed of PEI(polyethyleneimine)and heparin on the surface through layer by layer self-assembly driven by electrostatic force.Through this work,the PMP composite membrane with asymmetric structure was prepared,and the effects of modification conditions on the surface structure and composition,gas transport,blood compatibility and other properties of the composite membrane were studied.The result showed that the PEI-heparin modification layer introduced by layer-by-layer self-assembly greatly improved the gas transport performance and blood compatibility of the PMP hollow fiber composite membrane,which gave it important application potential in the fields of gas separation and membrane oxygenation.

关 键 词：聚-4-甲基-1-戊烯(PMP) 层层自组装 抗凝血非对称 CO_(2)气体传输 

分 类 号：R318.08[医药卫生—生物医学工程] TB324[医药卫生—基础医学] TQ028[一般工业技术—材料科学与工程]