矮小症儿童骨密度与25羟维生素D相关性分析  

Analysis of the correlation between bone mineral density and 25 hydroxyvitamin D in children with short stature

作　　者：石淑霞[1] 彭武[2] SHI Shu-xia;PENG Wu(Department of Pediatrics,The Second Affiliated Hospital of Anhui Medical University,Hefei 230601,Anhui;Department of Clinical Medicine,Anhui Medical College,Hefei 230601,Anhui)

机构地区：[1]安徽医学高等专科学校临床医学院,安徽合肥230601 [2]安徽医科大学第二附属医院儿科,安徽合肥230601

出　　处：《安徽医专学报》2024年第3期82-84,88,共4页Journal of Anhui Medical College

基　　金：安徽省高校优秀青年人才支持计划项目(编号:gxyq2019191)。

摘　　要：目的:探讨矮小症儿童的骨密度,分析骨密度与25羟维生素D的相关性。方法:将88例矮小症儿童列为观察组,与88例身高正常儿童的骨密度比较;分析观察组骨密度与25羟维生素D的相关性。根据是否生长激素缺乏、是否青春发育、维生素D营养状态将观察组进行分类,比较各类状态的骨密度。结果:观察组儿童的骨密度Z值低于对照组(P=0.004)。矮小症儿童基线骨密度Z值与25羟维生素D无相关性(r=0.007,P=0.947)。生长激素缺乏症组的骨密度Z值低于特发性矮身材组,但差异无统计学意义(P=0.321)。青春期组儿童的骨密度Z值低于青春期前组,差异有统计学意义(P=0.001)。维生素D不足组的矮小儿童骨密度与年龄、骨龄呈负相关(r=-0.579、-0.573,P<0.001),与25羟维生素D无相关性(P=0.436)。结论:矮小症儿童骨密度Z值低于身高正常儿童,青春发育者尤明显;25羟维生素D值不能反映矮小症儿童的骨密度水平,骨量积累不足需考虑时间累积效应。Objective:To investigate the bone mineral density(BMD)in children with short stature and analyze the correlation between baseline BMD and 25 hydroxyvitamin D.Methods:The BMD of 88 children with short stature was compared with that of 88 children with normal height.The correlation between BMD and 25 hydroxyvitamin D of observation group was analyzed.The observation group was classified according to growth hormone deficiency,puberty or not and vitamin D nutritional status,and the bone mineral density of different states was compared respectively.Results:The bone mineral density Z-score of observation group was lower than that of control group(P=0.004).There was no correlation between baseline bone mineral density Z-score and 25 hydroxyvitamin D in children with nanosomia was found(r=0.007,P=0.947).The bone mineral density Z-score of the growth hormone deficiency group was lower than that of the idiopathic short stature group,but the difference was not statistically significant(P=0.321).The bone mineral density Z-score of the adolescent group was lower than that of the preadolescent group,and the difference was statistically significant(P=0.001).BMD Z-score was negatively correlated with age and bone age(r=-0.579,-0.573,P<0.001),but no correction with 25-hydroxyvitamin D was discovered(P=0.436).Conclusion:The bone mineral density Z-score in children with nanosomia was lower than that in children with normal height,especially in those with pubertal development.Baseline 25 hydroxyvitamin D does not illustrate BMD level in children with nanosomia,and the time cumulative effect of insufficient bone mass accumulation should be considered.

关 键 词：矮小症 儿童 骨密度 25羟维生素D 生长激素缺乏症 

分 类 号：R725.8[医药卫生—儿科]