太原市某社区老年高血压病患者骨量异常的影响因素  

Influencing factors for abnormal bone mass in elderly patients with hypertension in a community of Taiyuan City

作　　者：李玥涟 谢国晓 薛雪花[1] 赵凌霞[1] Li Yuelian;Xie Guoxiao;Xue Xuehua;Zhao Lingxia(Department of Endocrinology and Metabolism,Third Hospital of Shanxi Medical University,Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Tongji Shanxi Hospital,Taiyuan 030032,China)

机构地区：[1]山西医科大学第三医院·山西白求恩医院·山西医学科学院·同济山西医院内分泌科,太原030032

出　　处：《中华老年多器官疾病杂志》2024年第6期427-430,共4页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：山西省卫生计生委科研课题(2018GW26)。

摘　　要：目的 探讨太原市某社区老年高血压病患者骨量异常的影响因素,为老年高血压病患者预防及治疗骨质疏松提供理论依据。方法 回顾性分析2021年1月至2022年12月在太原市某社区卫生服务中心登记的198例老年高血压病患者的临床资料。根据骨密度T值将患者分为骨量正常组(T≥-1.0,n=97)和骨量异常组(T<-1.0,n=101),比较两组患者相关生化指标的差异。采用SPSS 25.0统计软件进行数据分析。根据数据类型,分别采用t检验、Mann-Whitney U检验或χ^(2)检验进行组间比较。采用Spearman相关分析一般生化指标与骨量的相关性。采用二元logistic回归分析骨量异常的独立影响因素。结果 骨量正常组与骨量异常组性别、年龄、收缩压、舒张压、白蛋白、25-羟基维生素D及血钙水平比较,差异有统计学意义(P<0.05)。性别、年龄、收缩压、舒张压、血尿素氮(BUN)与腰椎骨量呈负相关(r=-0.287,-0.293,-0.479,-0.201,-0.208;P<0.05);25-羟基维生素D及白蛋白与腰椎骨量呈正相关(r=0.346,0.151;P<0.05)。二元logistic回归分析显示,年龄、性别、收缩压及舒张压为腰椎骨量的独立影响因素(P<0.05)。结论 性别、年龄及血压是高血压病患者骨量异常的独立危险因素,老年高血压病患者要密切监测血压及骨密度值,将骨质疏松性骨折的风险降到最低。Objective To investigate the influencing factors for abnormal bone mass in elderly hypertension patients in a community of Taiyuan City in order to provide theoretical basis for the prevention and treatment of osteoporosis in these patients.Methods Clinical data of 198 elderly patients with hypertension registered in a community health service center of Taiyuan City from January 2021 to December 2022 were collected and retrospectively analyzed.According to the results of bone mineral density test,they were divided into normal bone mass group(T≥-1.0,n=97)and abnormal bone mass group(T<-1.0,n=101).The relevant biochemical indicators were compared between the two groups.SPSS statistics 25.0 was used to perform the statistical analysis.Student′s t test,Mann-Whitney U test or Chi-square test was employed for intergroup comparison depending on data type.Spearman correlation analysis was performed on the correlation of common biochemical indicators and bone mass.Binary logistic regression analysis was applied to analyze the independent influencing factors for abnormal bone mass.Results There were significant differences in terms of gender,age,systolic blood pressure(SBP),diastolic blood pressure(DBP),albumin,25-hydroxyvitamin D[25(OH)D]and blood calcium level between the normal and abnormal bone mass groups(P<0.05).Lumbar bone density was negatively correlated with gender,age,SBP,DBP and blood urea nitrogen(BUN)(r=-0.287,-0.293,-0.479,-0.201,-0.208;P<0.05),and positively with 25(OH)D and albumin(r=0.346,0.151;P<0.05).Binary logistic regression analysis showed that age,gender,SBP and DBP were independent influencing factors for lumbar bone density(P<0.05).Conclusion Gender,age and blood pressure are independent risk factors for abnormal bone mass in hypertension patients.Blood pressure and bone mineral density should be closely monitored in elderly hypertension patients in order to minimize the risk of osteoporotic fractures.

关 键 词：高血压 骨密度 生化指标 

分 类 号：R544.1[医药卫生—心血管疾病]