三酰甘油-葡萄糖指数(TyG)与中老年人新发脑卒中风险的关联性研究  

Association between triglyceride-glucose index (TyG) and the risk of new-onset stroke in middle-aged and elderly people

作　　者：方奎 张晶[2] 朱晨[2] 代坤 余立平[1] FANG Kui;ZHANG Jing;ZHU Chen;DAI Kun;YU Liping(School of Nursing,Wuhan University,Wuhan,Hubei 430071,China;Neurosurgery Department,The First Affiliated Hospital of China Medical University,Shenyang 110001,China;School of Public Health,Wuhan University,Wuhan,Hubei 430071,China)

机构地区：[1]武汉大学护理学院,湖北武汉430071 [2]中国医科大学附属第一医院神经外科,辽宁沈阳110001 [3]武汉大学公共卫生学院,湖北武汉430071

出　　处：《公共卫生与预防医学》2024年第4期37-40,共4页Journal of Public Health and Preventive Medicine

基　　金：国家自然青年科学基金项目(82103450)。

摘　　要：目的 脑卒中的高发病率、高致残率和高致死率导致了沉重的经济和社会负担。研究旨在探究三酰甘油-葡萄糖(triglyceride-glucose,TyG)指数与新发脑卒中之间的关系以协助识别脑卒中高危人群并提供有效预防思路。方法 该研究基于2011—2018年中国健康与退休纵向研究(China Health and Retirement Longitudinal Study,CHARLS)的数据,纳入了7 630名符合条件的中老年参与者。通过logistic回归模型和限制性三次样条分析评估了TyG指数与新发脑卒中之间的关联。结果 总计431名参与者新发脑卒中。TyG当TyG指数>8.523时,其为脑卒中发生的危险因素,TyG每上升一个单位新发生脑卒中的风险增加74%(OR=1.74,95%CI:1.43~2.10)。结论 TyG指数升高是新发脑卒中的危险因素。该研究为脑卒中的高危人群识别和干预措施及时机提供了新的思路。Objective The high incidence,disability,and mortality rates of stroke result in a heavy economic and social burden.The aim of this study was to investigate the relationship between triglyceride-glucose(TyG) index and new-onset stroke to assist in the identification of high-risk groups for stroke and to provide ideas for effective prevention.Methods The study was based on data from the China Health and Retirement Longitudinal Study(CHARLS) from 2011 to 2018 and included 7 630 eligible middle-aged and elderly participants.The association between TyG index and new-onset stroke was assessed by logistic regression modelling and restricted triple spline analysis.Results A total of 431 participants had a new stroke.The TyG index was found to be a risk factor for stroke occurrence when it was >8.523,and there was a positive linear association moderated by gender.Conclusion Elevated TyG index is a risk factor for new stroke.This study provides new ideas for the identification of high-risk groups for stroke and for intervention measures and timing.

关 键 词：三酰甘油-葡萄糖指数 TyG 脑卒中 相关性研究 剂量反应关系 中国健康与养老追踪调查 

分 类 号：R181[医药卫生—流行病学]