南通地区乙型肝炎肝癌患者的流行病学特征及HBV-DNA变化趋势  

Epidemiological characteristics and trend of HBV-DNA changes in patients with hepatitis B and liver cancer in Nantong region

作　　者：张弛 马庆霞 顾益凤[1] ZHANG Chi;MA Qingxia;GU Yifeng(Laboratory Department of Nantong Cancer Hospital,Nantong,Jiangsu 226361,China)

机构地区：[1]江苏省南通市肿瘤医院检验科,江苏南通226361

出　　处：《公共卫生与预防医学》2024年第4期95-98,共4页Journal of Public Health and Preventive Medicine

摘　　要：目的 根据2019—2022年南通地区乙型肝炎肝癌患者的流行情况,分析乙型肝炎病毒DNA(HBV-DNA)变化趋势,为乙型肝炎肝癌的防治提供理论依据。方法 收集南通市肿瘤医院的乙型肝炎肝癌患者资料,统计其一般资料、感染乙肝时间以及HBV-DNA定量检测结果,分析乙型肝炎肝癌患者HBV-DNA定量检查结果的变化趋势。结果 共收集乙型肝炎肝癌患者487例,男性395例,女性92例,其中51~60岁患者最多(28.34%),其次为41~50岁(23.00%)和61~70岁(21.56%)。除了感染时间不详患者84例外,患者的乙肝感染时间大部分分布在11~20年,其次为21~30年和1~10年。除HBV-DNA水平不详患者126例外,361例患者中HBV-DNA阳性率为64.82%。2019—2022年间除HBV-DNA水平不详患者之外,HBV-DNA<500 copies/mL患者占比呈上升趋势,HBV-DNA在(10~3~10~6)copies/mL的患者占比呈下降趋势。结论 性别、感染乙肝时间均为乙肝肝癌的高危因素,大部分肝癌患者HBV-DNA为阳性,需要定期对其进行检测,以指导抗病毒治疗。Objective Based on the epidemic situation of hepatitis B and liver cancer patients in Nantong from 2019 to 2022,to analyze the trend of hepatitis B virus DNA(HBV-DNA) changes and provide theoretical basis for the prevention and treatment of hepatitis B and liver cancer.Methods The data of patients with hepatitis B and liver cancer in Nantong Cancer Hospital were collected,and the general data,the time of infection with hepatitis B and the results of quantitative HBV-DNA test were statistically analyzed.Results A total of 487 patients with hepatitis B and liver cancer were collected,including 395 males and 92 females.Among them,patients aged 51-60 were the most common,accounting for 28.34%,followed by those aged 41-50 and 61-70,accounting for 23.00% and 21.56% respectively.In addition to 84 patients with unknown infection time,most of the patients with hepatitis B infection time distributed in 11 to 20 years,followed by 21 to 30 years and 1 to 10 years.Except for 126 patients with unknown levels of HBV DNA,the positive rate of HBV DNA in 361 patients was 64.82%.Between 2019 and 2022,except for patients with unknown levels of HBV-DNA,the proportion of patients with HBV-DNA<500 copies/mL showed an upward trend,while the proportion of patients with HBV-DNA(103-106) copies/mL showed a downward trend.Conclusion Sex and the time of infection with hepatitis B are high risk factors for hepatitis B liver cancer.Most patients with liver cancer are positive for HBV-DNA,which needs to be tested regularly to guide antiviral treatment.

关 键 词：乙型肝炎 肝癌 乙型肝炎病毒 家族史 

分 类 号：R181[医药卫生—流行病学]