初级纤毛相关信号通路在伤口愈合和瘢痕演变中的作用  

Advances in the Role of Primary Cilia Related Signaling Pathways in Wound Healing and Scar Evolution

作　　者：李珍玲[1] 郑振龙[1] 金哲虎[1] LI Zhenling;ZHENG Zhenlong;JIN Zhehu(Department of Dermatology,Yanbian University Hospital,Yanji 133000,China)

机构地区：[1]延边大学附属医院皮肤科,吉林延吉133000

出　　处：《中国皮肤性病学杂志》2024年第7期709-714,共6页The Chinese Journal of Dermatovenereology

基　　金：国家自然科学基金项目(82260617,82060569);吉林省卫生技术创新项目(2017J095)。

摘　　要：初级纤毛是突出于细胞表面的一种信号感受器,由于它们对多种信号通路不可或缺,因而被视为调节细胞功能的“枢纽”。纤毛的结构和功能缺失会引起一系列纤毛病,研究发现纤毛对伤口愈合和瘢痕演变过程也有一定贡献。本文结合初级纤毛的结构与功能,着重讨论初级纤毛在瘢痕形成相关信号通路中的作用,为病理性瘢痕的治疗提供新思路。Primary cilia are signal receptors that protrude from the cell surface.They are regarded as"hubs"for regulating cell processes since they are indispensable to a variety of signaling pathways.The structural and functional deficiencies of cilia cause a range of ciliopathies,and studies have revealed that cilia also play a role in wound healing and scar evolution.This review focuses on the role of primary cilia in scar evolution related signaling pathways,which may lead to a new approach to treating pathological scars.

关 键 词：初级纤毛 伤口愈合 病理性瘢痕 信号通路 

分 类 号：R751[医药卫生—皮肤病学与性病学] R363[医药卫生—临床医学]