肠道类器官基因编辑技术的研究进展  

Research progress on gene⁃editing technology of intestinal organoids

作　　者：周寅 俞静[1] 丁国宪[1] ZHOU Yin;YU Jing;DING Guoxian(Department of Geriatric Endocrinology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院老年内分泌科,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2024年第7期979-984,共6页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家重点研发计划(2022YFA0806100)。

摘　　要：肠道类器官是一种新兴的实验模型,具有模拟体内器官结构和功能的特性,广泛用于肠道疾病与功能变化的研究。近年来,研究者们将基因编辑与肠道类器官结合,为探究疾病的发生机制和研发针对性的治疗手段提供了可能。本篇综述旨在回顾基因编辑技术在肠道类器官中的应用,并探讨其在疾病建模、药物研发等领域的发展前景。Intestinal organoid is a new experimental model and is widely used in research on intestinal diseases and functional changes for its property in mimicking structures and functions of in vivo organs.In recent years,researchers have combined gene-editing technology with intestinal organoids,offering possibilities for elucidating the mechanisms of diseases and developing targeted therapies for these diseases.This review looks back on the applications of gene-editing in intestinal organoids and their future perspectives in disease modeling and drug development.

关 键 词：肠道类器官 干细胞 基因编辑 

分 类 号：Q78[生物学—分子生物学]