COVID-19疫情暴发后急性PACG发作影响因素分析  

Analysis of the factors influencing the onset of acute PACG after COVID-19 outbreak

作　　者：卢亚楠 丁文君 陈霄雅 李甦雁 苗培建 赵金巧 司沛波 Lu Yanan;Ding Wenjun;Chen Xiaoya;Li Suyan;Miao Peijian;Zhao Jinqiao;Si Peibo(Department of Ophthalmology,The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University,Xuzhou First People's Hospital,Eye Disease Prevention and Treatment Institute of Xuzhou,Xuzhou 221000,China)

机构地区：[1]徐州医科大学附属徐州市立医院、徐州市第一人民医院眼科、徐州市眼病防治研究所,徐州221000

出　　处：《中华实验眼科杂志》2024年第6期532-537,共6页Chinese Journal Of Experimental Ophthalmology

基　　金：江苏省青年医学重点人才培养计划(QNRC2016364)。

摘　　要：目的分析新型冠状病毒感染(COVID-19)疫情暴发后急性原发性闭角型青光眼(PACG)患者在拟行青光眼手术患者中的构成比及发病的影响因素。方法采用横断面研究,以整群抽样法,通过医院信息化系统收集COVID-19疫情暴发后徐州市第一人民医院2022年12月16日至2023年1月16日住院拟行青光眼手术的患者141例及2021—2022、2020—2021、2019—2020年同期(12月16日至次年1月16日)住院拟行青光眼手术的患者231例。选取其中疫情暴发后急性PACG患者92例92眼为研究组,2021—2022年同期住院的急性PACG患者21例21眼为对照组。分析观察期内拟行手术的各类型青光眼患者构成比和急性PACG患者在拟行青光眼手术患者中的构成比及其临床特征,包括年龄、性别、视力、眼压、房角关闭程度。通过电话回访形式获得患者COVID-19后抗感冒药物服用情况、生活习惯和心理情绪变化(包括日饮水量和焦虑)等流行病学资料,采用医院抑郁和焦虑量表(HADS)评估研究组患者焦虑程度,分析疫情暴发后急性PACG患者发作的诱发因素。结果疫情暴发后1个月内徐州市第一人民医院急性PACG患者占比较2021—2022、2020—2021及2019—2020年同期显著增加,差异均有统计学意义(χ2=31.066、33.331、20.804,均P<0.001)。研究组与对照组不同等级视力眼数分布情况、眼压、眼压≥30 mmHg(1 mmHg=0.133 kPa)者及不同房角状态眼数分布情况比较,差异均无统计学意义(均P>0.05)。对照组发病期间患者无COVID-19及服用抗感冒药物等病史。研究组发病期间92例(占100%)患者新型冠状病毒核酸检测结果均为阳性,其中57例(占61.96%)有口服抗感冒药物史;同期住院其他类型青光眼患者49例,新型冠状病毒核酸检测结果均为阳性(占100%),20例(占40.82%)有口服抗感冒药物史。研究组急性PACG患者和同期其他类型青光眼患者口服抗感冒药物人数占比比较,差异有统计学意Objective To analyze the proportion of patients with acute primary angle-closure glaucoma(PACG)after the outbreak of coronavirus disease 2019(COVID-19)in patients undergoing glaucoma surgery and the factors influencing morbidity.Methods A cross-sectional study was performed.The cluster sampling method was used to collect 141 glaucoma patients hospitalized for glaucoma surgery after the outbreak of COVID-19 in Xuzhou First People's Hospital from December 16,2022,to January 16,2023,and 231 glaucoma patients hospitalized for surgery in the same 1-month period from 2019 to 2020,2020 to 2021,2021 to 2022 through the hospital information system.Ninety-two eyes of 92 patients with acute PACG after the outbreak were selected as a study group,and 21 eyes of 21 patients with acute PACG hospitalized during the same 1-month period from 2021 to 2022 were selected as a control group.The proportion of patients with different types of glaucoma during the observation period was analyzed.The proportion of patients with acute PACG and the clinical characteristics of acute PACG were analyzed,including age,sex,visual acuity,intraocular pressure(IOP),and anterior chamber angle status.Epidemiological data such as the use of anti-cold medications,and changes in living habits and moods(including daily water intake and anxiety)of patients after COVID-19 infection were obtained by telephone follow-up.Anxiety levels of patients in the study group were assessed using the Hospital Depression and Anxiety Scale(HADS).The triggering factors of acute PACG attack after the COVID-19 outbreak were analyzed.This study adhered to the Declaration of Helsinki.The study protocol was approved by the Ethics Committee of Xuzhou First People's Hospital(No.xyyll[2023]114).Written informed consent was obtained from each subject.Results The proportion of acute PACG patients in Xuzhou First People's Hospital within one month after the outbreak in 2022 to 2023 increased significantly compared with the same period in 2021 to 2022,2020 to 2021 and 2019 to 2020,and

关 键 词：新型冠状病毒感染 青光眼 发病率 急性原发性闭角型青光眼 影响因素 焦虑 

分 类 号：R511[医药卫生—内科学] R779.6[医药卫生—临床医学]