基于药智网数据库挖掘中药露蜂房的配伍规律及应用特点  

Mining of the Compatibility and Application Characteristics of Chinese Medicine Nidus Vespae Based on the Pharmacy Intelligence Network Database

作　　者：张凤 钟娟 潘文波 ZHANG Feng;ZHONG Juan;PAN Wen-bo(Yichun Second People's Hospital,Yichun,336000,China)

机构地区：[1]宜春市第二人民医院,宜春336000

出　　处：《神经药理学报》2024年第2期20-25,共6页Acta Neuropharmacologica

摘　　要：目的:基于数据挖掘探讨含露蜂房方剂的配伍规律及应用特点,为露蜂房合理用药提供参考。方法:收集药智网数据库中含露蜂房的方剂,构建露蜂房方剂数据库,运用Microsoft Office Excel 2019、IBM SPSS Modeler 18.0、IBM SPSS Statistics 23.0等软件统计方剂所含中药的性味、归经、功效、主治等,并进行高频中药的关联规则分析及聚类分析。结果:147首符合纳入要求的方剂涉及中药353味,1597次的累计使用频次中以攻毒杀虫止痒药、清热药、活血化瘀药最为常用,药性以温性、寒性为主,药味多甘、辛、苦,主要归肝、胃、脾、心经。21味高频中药的29项关联规则中支持度、置信度依次位列前三是“露蜂房-蛇蜕”、“露蜂房-当归”、“露蜂房-穿山甲”。含露蜂房方剂主治痈疽、牙疼、痔疮、风湿等疾病,分析露蜂房治痈疽方剂得到19味高频中药及其4个类方。结论:该研究通过数据挖掘分析了含露蜂房方剂的配伍特点及组方规律,可为露蜂房的临床应用及新药开发提供参考。Objective:Based on data mining,the compatibility and application characteristics of formulas containing Nidus Vespae were discussed to provide references for rational drug use in honeycombs.Methods:Collect the prescriptions of Nidus Vespae in the Pharmacy Intelligence network database,construct Nidus Vespae prescription database,Microsoft Office Excel 2019,IBM SPSS Modeler 18.0,and IBM SPSS Statistics 23.0 were used to analyze the properties,flavors,Meridian Tropism,efficacy,and indications of Chinese herbal medicines.Association rules and cluster analysis were also conducted for high-frequency Chinese herbal medicines.Results:Among the 147 prescriptions that met the inclusion requirements,353 Chinese herbs were used.Among the 1597 cumulative uses,the most commonly used medicines were anti-toxin,insecticides,antipruritic drugs,heat-clearing drugs and drugs for promoting blood circulation and removing blood stasis,the medicine taste is more sweet,bitter and pungent,and mainly belongs to liver,stomach,spleen and heart meridian.The support and confidence of the 29 Association rules of 21 high-frequency Chinese herbal medicines were“Nidus Vespae-snake shed”,“Nidus Vespae-angelica”and“Nidus Vespae-pangolin”.the prescriptions of Nidus Vespae were mainly used to treat carbuncle,toothache,hemorrhoid,rheumatism and other diseases,19 kinds of high-frequency Chinese herbs and 4 kinds of New Prescriptions were obtained by analyzing the prescriptions of treating carbuncle.Conclusion:In this study,data mining was used to analyze the compatibility characteristics and composition rules of formulas containing Nidus Vespae,which can provide references for clinical application and new drug development of Nidus Vespae.

关 键 词：露蜂房 数据挖掘 配伍规律 应用特点 

分 类 号：R289[医药卫生—方剂学] R932[医药卫生—中药学]