足细胞SIRT1/FoxO3自噬通路与糖尿病肾脏疾病关系的研究进展  

Research Progress of Relationship between Autophagy Pathway of SIRT1/FoxO3 Podocytes and Diabetic Kidney Disease

作　　者：于涛 陈亚巍 YU Tao;CHEN Yawei(Cadre Ward Departments Three,Joint Logistics Support Force 983rd Hospital,Tianjin 300142,China)

机构地区：[1]联勤保障部队第九八三医院干部病房三科,天津300142

出　　处：《医学综述》2024年第15期1813-1817,共5页Medical Recapitulate

摘　　要：糖尿病肾脏疾病(DKD)是糖尿病微血管并发症之一,也是目前全球范围内导致终末期肾病的首要原因,足细胞在DKD发病机制中发挥重要作用,而自噬对维持足细胞生存及内环境稳定具有重要意义。因此,自噬及相关通路是DKD的潜在治疗干预靶点。沉默信息调节因子1通过介导叉头框转录因子O3的去乙酰化,激活足细胞自噬相关通路,调节自噬相关基因和氧化应激反应,维持足细胞结构和功能,从而延缓DKD的进展。未来对足细胞自噬相关通路与DKD发病机制的关系进行深入探索,将为DKD的临床诊断和靶向治疗提供新思路。Diabetic kidney disease(DKD)is one of the main complications of diabetic microvascular damage,which is also the leading cause of end-stage renal disease all over the world.Podocytes play an important role in the pathogenesis of DKD,and autophagy is of great significance in maintaining the survival of podocytes and the stability of the internal environment.Therefore,autophagy and its associated pathways are potential therapeutic intervention targets for DKD.Silent information regulator 1 activates the autophagy-related pathway,regulates autophagy related genes,regulates oxidative stress response,maintains podocyte structure and function by mediating the deacetylation of forkhead box O3,thus delays the progression of DKD.In the future,in-depth exploration of the relationship between the autophagy-related pathway of podocytes and the pathogenesis of DKD will provide new ideas for the clinical diagnosis and targeted treatment of DKD.

关 键 词：糖尿病肾脏疾病 足细胞 自噬 沉默信息调节因子1 叉头框转录因子O3 

分 类 号：R587.2[医药卫生—内分泌]