重组牛碱性成纤维细胞生长因子凝胶联合蒙脱石散对婴幼儿尿布疹的疗效观察与研究  

Observation and study on the efficacy of recombinant bovine basic fibroblast growth factor gel combined with montmorillonite powder in infant diaper rash

作　　者：陈晓明[1] 刘华之[2] 罗艳[1] 黄华春[1] 曾小青[1] 陈高平 CHEN Xiaoming;LIU Huazhi;LUO Yan;HUANG Huachun;ZENG Xiaoqing;CHEN Gaoping(Department of Dermatology,the First Affiliated Hospital of Gannan Medical University,Ganzhou,Jiangxi,341000,China;Department of Ospital Infection,the First Affiliated Hospital of Gannan Medical University,Ganzhou,Jiangxi,341000,China;Department of Orthopedics,Shicheng County People's Hospital,Ganzhou,Jiangxi,342700,China)

机构地区：[1]赣南医学院第一附属医院皮肤科,江西赣州341000 [2]赣南医学院第一附属医院院感科,江西赣州341000 [3]石城县人民医院骨科,江西赣州342700

出　　处：《当代医学》2024年第10期84-88,共5页Contemporary Medicine

基　　金：赣州市指导性科技计划项目(GZ2020ZSF028)。

摘　　要：目的探究重组牛碱性成纤维细胞生长因子(rbFGF)凝胶联合蒙脱石散对婴幼儿尿布疹的临床效果。方法选取2019年12月至2020年6月赣南医学院第一附属医院收治的72例婴幼儿尿布疹患儿作为研究对象,按照随机数字表法分为对照组与实验组,每组36例。对照组给予rbFGF凝胶干预,实验组在对照组基础上联合蒙脱石散干预,比较两组干预效果、恢复情况、皮肤损伤程度、血清学指标及不良反应发生情况。结果实验组治疗总有效率为94.44%,高于对照组的72.22%,差异有统计学意义(P<0.05)。干预后,两组皮肤发红、皮肤破裂面积及皮肤侵蚀程度评分均低于干预前,且实验组低于对照组,差异有统计学意义(P<0.05)。实验组不良反应发生率为5.56%,低于对照组的25.00%差异有统计学意义(P<0.05)。实验组尿布疹消退时间、住院时间均短于对照组,差异有统计学意义(P<0.05)。干预后,两组肿瘤坏死因子-α(TNF-α)、白细胞介素-4(IL-4)、白细胞介素-10(IL-10)水平均低于干预前,干扰素-γ(IFN-γ)水平高于干预前,且实验组TNF-α、IL-4、IL-10水平低于对照组,IFN-γ水平高于对照组,差异有统计学意义(P<0.05)。结论rbFGF凝胶联合蒙脱石散应用于婴幼儿尿布疹的疗效显著,可减轻皮肤损伤程度,改善机体炎症反应,缩短尿布疹消退时间,且不良反应少,值得临床推广应用。Objective To study the clinical effect of recombinant bovine basic fibroblast growth factor(rbFGF)gel combined with montmorillonite powder on infant diaper rash.Methods 72 infants with diaper rash who were treated in the First Affiliated Hospital of Gannan Medical University from December 2019 to June 2020 were selected as the research subjects,and they were divided into the control group and the experimental group according to the random number table method,with 36 cases in each group.The control group was given rbFGF gel intervention,and the experimental group was combined with montmorillonite powder intervention on the basis of the control groupn,the intervention effect,recovery,skin injury degree,serological indexes and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the experimental group was 94.44%,which was higher than 72.22%in the control group,and the difference was statistically significant(P<0.05).After intervention,the scores of skin redness,skin rupture area and skin erosion degree of the two groups were lower than those before intervention,and the experimental group was lower than the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was 5.56%,which was lower than 25.00%in the control group,and the difference was statistically significant(P<0.05).The disappearance time of diaper rash and hospitalization time in the experimental group were shorter than those in the control group,the differences were statistically significant(P<0.05).After intervention,the levels of tumor necrosis factor-α(TNF-α),interleukin-4(IL-4)and interleukin-10(IL-10)of the two groups were lower than those before intervention,and the level of interferon-γ(IFN-γ)was higher than that before intervention,and the levels of TNF-α,IL-4 and IL-10 in the experimental group were lower than those in the control group,and the level of IFN-γwas higher than that in the control group,the differences wer

关 键 词：重组牛碱性成纤维细胞生长因子凝胶 蒙脱石散 婴幼儿尿布疹 皮肤损伤 干扰素-Γ 白细胞介素-4 

分 类 号：R758.22[医药卫生—皮肤病学与性病学]