低分子肝素钠联合拉贝洛尔治疗妊娠期高血压的临床疗效  

Clinical efficacy of low molecular weight heparin sodium combined with labetalol in the treatment of hypertensive disorder complicating pregnancy

作　　者：赵红峰 谢梦女 杨金金[1] ZHAO Hongfeng;XIE Mengnv;YANG Jinjin(Department of Internal Medicine,Changsha Maternal and Child Health Hospital,Changsha,Hu'nan,410000,China)

机构地区：[1]长沙市妇幼保健院内科,湖南长沙410000

出　　处：《当代医学》2024年第10期98-101,共4页Contemporary Medicine

摘　　要：目的探讨低分子肝素钠联合拉贝洛尔治疗妊娠期高血压(HDCP)的临床疗效。方法选取2021年3月至2022年5月长沙市妇幼保健院收治的80例HDCP患者作为研究对象,按照信封法分为对照组与研究组,每组40例。对照组在常规治疗基础上联合拉贝洛尔治疗,研究组在对照组基础上联合低分子肝素钠治疗。比较两组血压[舒张压(DBP)、收缩压(SBP)]水平、凝血功能[活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、凝血酶原时间(PT)、凝血酶时间(TT)]、妊娠结局。结果治疗后,两组SBP、DBP水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组APTT、PT、TT均长于治疗前,FIB水平均低于治疗前,且研究组APTT、PT、TT均长于对照组,FIB水平低于对照组,差异有统计学意义(P<0.05)。研究组自然分娩率高于对照组,剖宫产率低于对照组,差异有统计学意义(P<0.05);两组助产率比较差异无统计学意义。研究组胎儿宫内窘迫、胎盘早剥、产后出血、产后感染、早产、胎盘早剥、低体质量儿发生率均低于对照组,差异有统计学意义(P<0.05)。结论低分子肝素钠联合拉贝洛尔治疗HDCP效果显著,有利于保障患者妊娠结局,提高自然分娩率,降低不良结局发生率,值得临床推广应用。Objective To explore the clinical efficacy of low molecular weight heparin sodium combined with labetalol in the treatment of Hypertensive disorder complicating pregnancy(HDCP).Methods A total of 80 patients with HDCP admitted to Changsha Maternal and Child Health Hospital from March 2021 to May 2022 were selected as the research subjects,they were divided into the control group and the study group according to the envelope method,with 40 cases in each group.The control group was treated with labetalol on the basis of conventional treatment,and the study group was treated with low molecular weight heparin sodium on the basis of the control group.The blood pressure level(diastolic blood pressure[DBP],systolic blood pressure[SBP]),coagulation function(activated partial thromboplastin time[APTT],fibrinogen[FIB],prothrombin time[PT],thrombin time[TT])and pregnancy outcome were compared between the two groups.Results After treatment,the levels of SBP and DBP of the two groups were lower than those before treatment,and the study group were lower than the control group,the differences were statistically significant(P<0.05).After treatment,APTT,PT and TT of the two groups were longer than those before treatment,FIB levels were lower than those before treatment,and APTT,PT and TT in the study group were longer than those in the control group,FIB levels was lower than that in the control group,the differences were statistically significant(P<0.05).The natural delivery rate in the study group was higher than that in the control group,and the cesarean section rate was lower than that in the control group,the differences were statistically significant(P<0.05);there was no significant difference in midwifery rate between the two groups.The incidence of fetal distress,placental abruption,postpartum hemorrhage,postpartum infection,premature delivery,placental abruption and low birth weight in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Low molec

关 键 词：妊娠期高血压 低分子肝素钠 拉贝洛尔 

分 类 号：R714.246[医药卫生—妇产科学]