西黄胶囊联合常规四联抗结核方案治疗颈淋巴结结核临床观察  

Clinical Observation of Xihuang Capsules Combined with Conventional Quadruple Anti-Tuberculosis Regimen in the Treatment of Cervical Lymph Node Tuberculosis

作　　者：李想 LI Xiang(Heilongjiang Provincial Infectious Disease Prevention and Control Hospital,Harbin,Heilongjiang,China 150500)

机构地区：[1]黑龙江省传染病防治院,黑龙江哈尔滨150500

出　　处：《中国药业》2024年第S01期64-66,共3页China Pharmaceuticals

摘　　要：目的探讨西黄胶囊联合常规四联抗结核方案治疗颈淋巴结结核的临床疗效。方法选取医院2022年1月至12月收治的颈淋巴结结核患者56例,按治疗方法的不同分为观察组和对照组,各28例。两组均予常规四联抗结核治疗(乙胺丁醇+利福平+异烟肼+吡嗪酰胺),观察组患者加服西黄胶囊。两组患者均持续治疗6个月。结果观察组总有效率为96.43%,显著高于对照组的75.00%(P<0.05)。治疗后,观察组患者的CD_(4)^(+)T淋巴细胞水平及CD_(4)^(+)/CD_(3)^(+)显著高于对照组,CD_(3)^(+)T淋巴细胞水平显著低于对照组(P<0.05);观察组患者的白细胞介素1、白细胞介素6、肿瘤坏死因子-α水平均显著低于对照组(P<0.05)。观察组不良反应发生率为10.71%,与对照组的3.57%相当(P>0.05)。结论西黄胶囊联合常规四联抗结核方案治疗颈淋巴结结核,可改善患者的免疫功能,降低炎性因子水平。Objective To investigate the clinical efficacy of Xihuang Capsules combined with conventional quadruple anti-tuberculosis regimen in the treatment of cervical lymph node tuberculosis.Methods A total of 56 patients with cervical lymph node tuberculosis admitted to the hospital from January to December 2022 were selected and divided into the observation group and the control group according to different treatment methods,with 28 cases in each group.Both groups were treated with conventional quadruple anti-tuberculosis therapy(ethambutol+rifampicin+isoniazid+pyrazinamide),while the observation group was additionally treated with Xihuang Capsules.Both groups received continuous treatment for 6 months.Results The total effective rate in the observation group was 96.43%,which was significantly higher than 75.00% in the control group(P<0.05).After treatment,the levels of CD_(4)^(+)T lymphocytes and CD_(4)^(+)/CD_(3)^(+)in the observation group were significantly higher than those in the control group,while the levels of CD_(3)^(+)T lymphocytesin the observation group were significantly lower than those in the control group(P<0.05).The levels of interleukin-1,interleukin-6,and tumor necrosis factor-α in the observation group were significantly lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was 10.71%,which was similar to 3.57% in the control group(P>0.05).Conclusion Xihuang Capsules combined with conventional quadruple anti-tuberculosis regimen in the treatment of cervical lymph node tuberculosis can improve the immune function,reduce inflammatory factor levels.

关 键 词：西黄胶囊 四联抗结核方案 颈淋巴结结核 临床疗效 免疫功能 炎性因子 

分 类 号：R969.4[医药卫生—药理学] R978.7[医药卫生—药学]