急性冠状动脉综合征患者肠道微生物变化与血糖相关性分析  

Correlation Analysis of Changes in Gut Microbiota and Blood Glucose in Patients with Acute Coronary Syndrome

作　　者：贾晓静 王宇航 郭莉 JIA Xiaojing;WANG Yuhang;GUO Li(Zhangjiakou First Hospital,Zhangjiakou,Hebei,China 075000)

机构地区：[1]河北省张家口市第一医院,河北张家口075000

出　　处：《中国药业》2024年第S01期110-111,共2页China Pharmaceuticals

基　　金：河北省医学科学研究课题[20232071]。

摘　　要：目的探讨肠道菌群多样性与急性冠状动脉综合征(ACS)之间的相关性。方法选取医院2020年1月至2022年8月收治的患者96例,按是否发生ACS分为对照组与试验组,各48例。两组患者进行粪便样品采集,比较两组患者的肠道菌群和血糖变化。结果与对照组比较,试验组患者肠道微生物种类如变形菌门、克雷伯菌属、罗氏菌属、微球菌科、放线菌目占比显著升高(P<0.05);试验组患者的血糖显著升高(P<0.05)结论ACS患者的肠道微生物群变化与血糖水平升高之间存在相关性。通过调整肠道微生物与代谢紊乱间的关系,改善ACS患者的血糖控制,可为ACS的临床管理提供治疗思路与策略。Objective To investigate the correlation of gut microbiota diversity and acute coronary syndrome(ACS).Methods A total of 96 patients admitted to the hospital from January 2020 to August 2022 were selected and divided into the control group and the test group based on whether with ACS,with 48 cases in each group.The fecal samples in the two groups of patients were collected,the changes in gut microbiota and blood glucose levels between the two groups were compared.Results Compared with the those in the control group,the proportion of gut microbiota types such as Proteobacteria,Klebsiella,Roseburia,Micrococcaceae and Actinomycetales of the patients in the test group significantly improved(P<0.05).The blood sugar of the he patients in the test group significantly increased(P<0.05).Conclusion There is a correlation of changes in gut microbiota and elevated blood glucose levels in ACS patients.By adjusting the relationship between gut microbiota and metabolic disorders,improving blood glucose control in ACS patients can provide treatment ideas and strategies for clinical management of ACS.

关 键 词：肠道菌群 急性冠脉综合征 血糖 相关性 

分 类 号：R541[医药卫生—心血管疾病]