吸附破伤风疫苗加强免疫后7天抗体水平变化  

Changes in tetanus antibody levels after 7 days of booster immunization with adsorbed tetanus vaccine

作　　者：庄天从 吕新军[2,4] 王传林 ZHUANG Tiancong;LÜXinjun;WANG Chuanlin(Luoshan Street Community Health Service Center of Jinjiang City,Jinjiang 362200,China;不详)

机构地区：[1]晋江市罗山街道社区卫生服务中心,362200 [2]中国疾病预防控制中心病毒病预防控制所 [3]北京大学人民医院国家创伤救治中心 [4]中国医学救援协会动物伤害救治分会

出　　处：《首都公共卫生》2024年第2期91-94,共4页Capital Journal of Public Health

摘　　要：目的 明确吸附破伤风疫苗加强免疫后早期破伤风抗体(tetanus antibody, TAB)水平变化情况。方法 对2019—2021年在晋江市罗山街道社区卫生服务中心就诊的1978年以后出生的已完成含破伤风类毒素疫苗(tetanus toxoid-containing vaccine, TTCV)免疫规划5年以上的269例受试者加强免疫1剂破伤风类毒素(tetanus toxoid, TT),观察免疫后7 d TAB水平变化。结果 269例受试者中,加强免疫前TAB<0.01 IU/mL和0.01~0.09 IU/mL的受试者分别占29.4%和70.6%;加强免疫后7 d, TAB≥0.01 IU/mL的受试者达82.9%,TAB≥0.10 IU/mL的受试者达37.2%;加强免疫前后,不同TAB水平的受试者比例差异有统计学意义(χ2=123.05,P<0.001)。加强免疫后7 d,男、女性受试者中TAB≥0.10 IU/mL的受试者分别占35.6%和38.7%;12~<21岁、21~<31岁和31~42岁组受试者中TAB≥0.10 IU/mL的受试者分别占55.3%、36.8%和20.3%。结论 已完成全程TTCV免疫规划5年以上人群TT加强免疫后7 d约1/3的受试者可以获得有效免疫保护。Objective To clarify the changes in early tetanus antibody(TAB)levels after booster immunization with adsorbed tetanus vaccine.Methods A total of 269 subjects who were born after 1978,completed the immunization schedule with tetanus toxoid containing vaccine(TTCV)for more than 5 years and sought medical treatment at the Community Health Service Center of Luoshan street,Jinjiang city from 2019 to 2021,were vaccinated with a booster dose of tetanus toxoid(TT).The changes in TAB levels were observed after 7 days of administration.Results Among 269 subjects,before booster immunization,there were 29.4%and 70.6%of the subjects with TAB<0.01 IU/mL and 0.01-0.09 IU/mL,respectively.After 7 days of booster immunization,the subjects with TAB≥0.01 IU/mL and TAB≥0.10 IU/m accounted for 82.9%and 37.2%,respectively.There was a statistically significant difference in the proportion of subjects with different levels of TAB before and after booster immunization(χ2=123.05,P<0.001).After 7 days of booster immunization,35.6%and 38.7%of male and female subjects had a TAB≥0.10 IU/mL,respectively;among the subjects aged 12-<21,21-<31,and 31-42,the subjects with a TAB≥0.10 IU/mL accounted for 55.3%,36.8%,and 20.3%,respectively.Conclusions About one-third of the participants who have completed the entire TTCV immunization schedule for more than 5 years can receive the effective immune protection after 7 days of TT booster immunization.

关 键 词：破伤风 破伤风疫苗 加强免疫 破伤风抗体 

分 类 号：R186[医药卫生—流行病学]