微动力负压引流对烧伤患者创面愈合及LDH、CK及CK-MB水平的影响  

Effect of microdynamic negative pressure drainage on wound healing and LDH,CK and CK⁃MB levels in burn patients

作　　者：戴泽宇 郑健生[1] DAI Zeyu;ZHENG Jiansheng(Department of Plastic Surgery,909th Hospital Xiamen University Affiliated Southeast Hospital,Zhangzhou,Fujian,China,363000)

机构地区：[1]第九〇九医院·厦门大学附属东南医院烧伤整形科,福建漳州363000

出　　处：《分子诊断与治疗杂志》2024年第6期1011-1014,共4页Journal of Molecular Diagnostics and Therapy

基　　金：第九〇九医院自主科研项目(22ZD005)。

摘　　要：目的 分析微动力负压引流对烧伤患者创面愈合及乳酸脱氢酶(LDH)、肌酸激酶(CK)及肌酸激酶同工酶(CK-MB)水平的影响。方法 采用回顾性、单中心分析2022年5月至2023年1月期间第九〇九医院·厦门大学附属东南医院收治的137例烧伤患者,经纳入、排除标准,剔除36例患者,最后纳入101例患者进行研究,并根据治疗方案不同分为对照组50例(予以传统换药处理)与观察组51例(采用微动力负压引流治疗)。对比两组临床疗效、创面愈合情况、心肌酶谱水平及术后感染发生情况。结果 观察组(96.09%)的总有效率比对照组(84.00%)高,差异有统计学意义(P<0.05);治疗3周后两组创面疼痛度均降低,且观察组低于对照组,差异有统计学意义(P<0.05);观察组创面清洁时间、肉芽组织生长时间、创面愈合时间均短于对照组,差异有统计学意义(P<0.05);治疗3周后,两组LDH、CK-MB、CK水平均降低,且观察组均低于对照组,差异有统计学意义(P<0.05);观察组(5.88%)术后感染总发生率比对照组(20.00%)低,差异有统计学意义(P<0.05)。结论 应用微动力负压引流治疗烧伤患者的临床疗效佳,其有助于创面愈合,改善患者心功能,并有效降低感染的发生率。Objective To analyze the effect of microdynamic negative pressure drainage on wound healing and levels of lactate dehydrogenase(LDH),creatine kinase(CK)and creatine kinase-MB(CK-MB)in burn patients.Methods A retrospective,single-center analysis was performed on 137 burn patients admitted to the 99th Hospital and Southeast Hospital Affiliated to Xiamen University from May 2022 to January 2023.After applying inclusion and exclusion criteria,36 patients were excluded,leaving 101 patients for the study.These patients were divided into two groups:50 cases in the control group(treated with traditional dressing changes)and 51 cases in the observation group(treated with microdynamic negative-pressure drainage)based on differ-ent treatment protocols.The clinical outcomes,wound healing,cardiac enzyme profile levels and the occur-rence of postoperative infections were compared between the two groups.Results The total effective rate of the observation group(96.09%)was higher than that of the control group(84.00%),and the difference was sta-tistically significant(P<0.05).Wound pain level was reduced in both groups after 3 weeks of treatment and was lower in the observation group than in the control group,with a statistically significant difference(P<0.05).Wound cleaning time,granulation tissue growth time,and wound healing time of the observation group were shorter than those of the control group,and the difference was statistically significant(P<0.05).After 3 weeks of treatment,the levels of LDH,CK-MB,and CK were decreased in both groups,and they were all lower in the observation group than in the control group,with statistically significant differences(P<0.05).The total in-cidence of postoperative infections in the observation group(5.88%)was lower than that in the control group(20.00%),with statistically significant differences(P<0.05).Conclusion The clinical efficacy of applying microdynamic negative pressure drainage to treat burn patients is high.This treatment helps with wound heal-ing,improves cardiac function,and eff

关 键 词：微动力负压引流 烧伤 创面愈合 LDH CK CK-MB 

分 类 号：R644[医药卫生—外科学]