早期高压氧联合依达拉奉治疗急性一氧化碳中毒的疗效及对血清NT-proBNP、NLR及PLR水平的影响  

Effect of early hyperbaric oxygen combined with edaravone on the levels of serum NT⁃proBNP,NLR and PLR in the treatment of acute carbon monoxide poisoning

作　　者：高顺华 杨硕 唐峰 GAO Shunhua;YANG Shuo;TANG Feng(Department of Emergency Department,Guangde Hospital of Traditional Chinese Medicine,Guangde,Anhui,China,242200)

机构地区：[1]安徽省广德市中医院急诊科,安徽广德242200

出　　处：《分子诊断与治疗杂志》2024年第6期1117-1120,1129,共5页Journal of Molecular Diagnostics and Therapy

基　　金：安徽省卫生健康委科研项目(AHWJ2021J019)。

摘　　要：目的 探究早期高压氧联合依达拉奉治疗急性一氧化碳中毒的疗效及对患者血清N末端脑钠肽原(NT-proBNP)、中性粒细胞/淋巴细胞比值(NLR)及血小板-淋巴细胞比值(PLR)水平的影响。方法 选取广德市中医院2020年2月至2023年10月期间急诊收治的急性一氧化碳重度患者102例,按照治疗方案分为两组,所有患者均接受常规治疗,在常规治疗基础上给予早期高压氧治疗48例为对照组,在对照组基础上加用依达拉奉治疗54例为联合组。比较两组临床疗效、血清NT-proBNP、NLR及PLR水平及不良反应情况等。结果 联合组总有效率高于对照组,差异具有统计学意义(χ^(2)=4.262,P<0.05);与治疗前比较,联合组与对照组治疗后血清NT-proBNP、NLR及PLR水平均下降,且联合组低于对照组,差异具有统计学意义(t=7.363、6.870、3.489,P<0.05);相较对照组,联合组治疗期间不良反应发生率、随访3月并发症总发生率稍低,但差异不具有统计学意义(χ^(2)=1.021、3.474,P>0.05)。结论 早期高压氧联合依达拉奉应用于急性一氧化碳中毒治疗效果确切,可有效降低患者NT-proBNP、NLR及PLR水平,减少近期内并发症发生率,安全性良好。Objective To investigate the efficacy of early hyperbaric oxygen combined with edara-vone in the treatment of acute carbon monoxide poisoning and the effects on the levels of serum N-terminal brain natriuretic peptide(NT-proBNP),platelet-lymphocyte ratio(PLR)and neutrophil/lymphocyte ratio(NLR)in patients.Methods 102 patients with severe acute carbon monoxide from February 2020 to October 2023 admit-ted to the Guangde Hospital of Traditional Chinese Medicine were retrospectively selected and divided into a control group(48 cases)and a combination group(54 cases)based on the treatment plan.Both groups received conventional treatment,while the control group received early hyperbaric oxygen therapy on this basis.The combined group was treated with edaravone on the basis of the control group.The clinical efficacy,serum NT-proBNP,NLR and PLR levels and adverse reactions were compared between the two groups.Results Com-pared with the control group,the total effective rate of the combined group was significantly higher(χ^(2)=4.262,P<0.05).Additionally,the levels of serum NT-proBNP,NLR,and PLR after treatment in both groups de-creased,and the levels of the above indicators in the combination group were significantly lower(t=7.363,6.870,3.489,P<0.05).Compared with the control group,the total incidence of complications at 3 months of follow-up,the incidence of adverse reactions during treatment in the combination group were significantly lower(χ^(2)=1.021,3.474,P>0.05).Conclusion Early hyperbaric oxygen therapy combined with edaravone is effective in treating acute carbon monoxide poisoning.This treatment can significantly reduce the levels of NT-proBNP,NLR,and PLR in patients,decrease the incidence of complications in the short term,and is considered safe.

关 键 词：急性一氧化碳中毒 早期高压氧 依达拉奉 N末端脑利钠肽原 中性粒细胞-淋巴细胞比值 血小板-淋巴细胞比值 

分 类 号：R595.1[医药卫生—内科学]