细菌溶解产物胶囊对老年慢性阻塞性肺疾病患者血清补体C3、C4及免疫蛋白IgA、IgG、IgM表达的干预研究  

Intervention of bacterial lysate capsule on expressions of serum complements C3 and C4 and immunoglobulins IgA,IgG and IgM in elderly patients with chronic obstructive pulmonary disease

作　　者：李思灵 LI Si-Ling(Department of Respiratory and Critical Care Medicine,Taishan People′s Hospital,Taishan 529200,Guangdong,China)

机构地区：[1]台山市人民医院呼吸与危重症医学科,广东台山529200

出　　处：《吉林医学》2024年第7期1573-1576,共4页Jilin Medical Journal

基　　金：江门市科技计划项目[项目编号:2021YL09014]。

摘　　要：目的:研究细菌溶解产物胶囊(泛福舒)对老年慢性阻塞性肺疾病(COPD)患者血清补体C3、C4及免疫蛋白IgA、IgG、IgM表达的干预影响。方法:选取2021年7月~2022年9月在台山市人民医院治疗的老年COPD患者120例,稳定期和急性发作期患者各60例,两期患者随机分为常规治疗组和合用泛福舒治疗组,各30例,并选取同期入院体检的无肺部疾病老年人30例为对照组。分析治疗12 w后,不同方式治疗老年稳定期COPD患者血清补体C3、C4及免疫蛋白IgA、IgG、IgM水平、急性发作次数差值的比较研究;不同方式治疗老年急性发作期COPD患者血清补体C3、C4及免疫蛋白IgA、IgG、IgM水平、发作持续时间差值的比较研究;分析治疗前,老年COPD患者血清补体C3、C4及免疫蛋白IgA、IgG、IgM水平在稳定期、急性发作期及正常对照组的差异研究。结果:治疗前,急性发作期、稳定期及对照组三组患者血清补体C3、C4及免疫蛋白IgA、IgG、IgM差异具有统计学意义(P<0.05);且急性发作期与稳定期两组患者血清补体C3、C4及免疫蛋白IgA、IgG、IgM均低于对照组,差异有统计学意义(P<0.05),但急性发作期与稳定期患者两组之间血清补体C3、C4及免疫蛋白IgA、IgG、IgM变化不大,差异无统计学意义(P>0.05);稳定期患者治疗12 w后,合用泛福舒治疗组血清补体C3低于常规治疗组,C4及免疫蛋白IgA、IgG、IgM均高于常规组,差异有统计学意义(P<0.05);治疗后,合用泛福舒组急性发作次数低于常规组,差异有统计学意义(P<0.05);急性发作期患者治疗12 w后,合用泛福舒治疗组血清补体C3低于常规治疗组,C4及免疫蛋白IgA、IgG、IgM均高于常规组,差异有统计学意义(P<0.05)。治疗后,合用泛福舒治疗组急性发作时间显著短于常规组,差异有统计学意义(P<0.05)。结论:泛福舒治疗稳定期和急性发作期老年COPD患者均有效,可通过提高患者免疫功能,减少急性发作次数,缩短Objective To study the intervention effects of bacterial lysate capsule on the expressions of serum complements C3 and C4 and immunoglobulins IgA,IgG and IgM in elderly patients with chronic obstructive pulmonary disease(COPD).Method 120 elderly patients with COPD treated in the hospital from July 2021 to September 2022 were selected,including 60 cases in stable stage and 60 cases in acute attack stage.The patients in each stage were randomly divided into conventional treatment group and combined broncho-vaxom treatment group,with 30 cases in each group.30 elderly patients without pulmonary diseases admitted for physical examination during the same period were included in control group.After 12 weeks of treatment,the differences in serum complements C3 and C4,immunoglobulins IgA,IgG and IgM and the frequency of acute attacks in patients with stable COPD treated by different methods and levels of serum complements C3 and C4 and immunoglobulins IgA,IgG and IgM and duration of attack in elderly patients with acute attack of COPD treated by different methods were analyzed.The differences in serum complements C3 and C4 and immunoglobulins IgA,IgG and IgM levels in elderly patients with COPD in stable stage,acute stage and normal control group were analyzed before treatment.Results Before treatment,there were statistical differences in serum complements C3 and C4 and immunoglobulins IgA,IgG and IgM among acute attack stage group,stable stage group and control group(P<0.05).In addition,the levels of serum complements C3 and C4 and immunoglobulins IgA,IgG and IgM in acute attack group and stable stage group were lower than those in control group(P<0.05),but the above levels were not significantly changed between acute attack htoup and stable stage group(P>0.05).After 12 weeks of treatment,the level of serum complement C3 of patients in stable stage in combined broncho-vaxom treatment group was lower than that in conventional treatment group,while the levels of C4,IgA,IgG and IgM were higher than those in conventional tre

关 键 词：细菌溶解产物胶囊 慢性阻塞性肺疾病 血清补体 免疫蛋白 急性发作期 

分 类 号：R563[医药卫生—呼吸系统]