吡拉西坦对重型颅脑外伤的疗效观察  

Effect observation of piracetam injection on severe craniocerebral trauma

作　　者：吴雁飞 胡丕健 刘远洪 WU Yanfei;HU Pijian;LIU Yuanhong(Department of Neurosurgery of People’s Hospital of Xunwu County,Ganzhou,Jiangxi Province 342200,China)

机构地区：[1]江西省赣州市寻乌县人民医院神经外科,赣州342200

出　　处：《上海医药》2024年第8期26-29,共4页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的:探讨吡拉西坦注射液对重型颅脑外伤患者的影响。方法:纳入2021年8月—2022年7月江西省赣州市寻乌县人民医院接诊的重型颅脑损伤患者50例,按照随机数字表法分为两组,每组25例。对照组实施常规颅脑外伤治疗,观察组在对照组基础上实施吡拉西坦注射液静脉滴注治疗,4 g+氯化钠注射液250 mL,1次/d,连续治疗7 d。观察两组治疗前后免疫球蛋白水平、格拉斯哥昏迷评分(GCS)、血清炎症因子水平及脑血流指标变化情况。结果:干预后,两组免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)水平和GCS评分均高于干预前(P<0.05),且观察组高于对照组(P<0.05)。干预后,两组肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平低于干预前(P<0.05),且观察组低于对照组(P<0.05)。两组干预后脉搏波波速(Wv)、动态阻力(DR)水平低于干预前(P<0.05),平均血流量(Qmean)、平均血流速度(Vmean)则高于干预前(P<0.05),且观察组均优于对照组(P<0.05)。结论:吡拉西坦注射液治疗能够提升重型颅脑外伤的治疗预后,促进患者脑损伤后意识和神经功能恢复,改善免疫功能、炎症状态和脑血流状态,应用价值较高。Objective:To investigate the effect of piracetam injection on patients with severe craniocerebral trauma.Methods:Fifty patients with severe craniocerebral trauma admitted to Xunwu County People’s Hospital of Ganzhou,Jiangxi Province from August 2021 to July 2022 were included and divided into two groups with 25 cases in each group according to random number table method.The control group received routine craniocerebral trauma treatment,and the observation group received piracetam injection,4 g added into 250 mL sodium chloride injection,once/day on the basis of the control group,and was treated continuously for 7 days.The changes of immunoglobulin level,Glasgow coma score(GCS),serum inflammatory factor level and cerebral blood flow index were observed before and after treatment.Results:After intervention,the levels of immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM)and GCS in both groups were higher than those before intervention(P<0.05),and the observation group was higher than the control group(P<0.05).After intervention,the levels of tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in two groups were lower than those before intervention(P<0.05),and the observation group was lower than the control group(P<0.05).After intervention,the pulse wave velocity(WV)and dynamic resistance(DR)levels were lower than those before intervention(P<0.05),and the mean blood flow(Qmean)and mean blood flow velocity(Vmean)levels were higher than those before intervention(P<0.05),and the observation group was better than the control group(P<0.05).Conclusion:Piracetam injection can improve the prognosis of severe craniocerebral trauma,promote the recovery of consciousness and nerve function after brain damage,and improve immune function,inflammatory state and cerebral blood flow state,which has high application value.

关 键 词：重型颅脑外伤 吡拉西坦注射液 影响 

分 类 号：R651[医药卫生—外科学]