胸段食管鳞状细胞癌患者术后淋巴转移危险因素分析  

Analysis of risk factors for postoperative lymphatic metastasis in patients with thoracic esophageal squamous cell carcinoma

作　　者：山明刚 齐博[1] SHAN Minggang;QI Bo(Department of Thoracic Surgery,the First Affiliated Hospital of Xinxiang Medical University,Weihui 453100,Henan Province,China)

机构地区：[1]新乡医学院第一附属医院胸外科,河南卫辉453100

出　　处：《新乡医学院学报》2024年第7期680-683,共4页Journal of Xinxiang Medical University

摘　　要：目的探讨胸段食管鳞状细胞癌患者淋巴结转移的危险因素。方法选择2020年1月至2022年6月于新乡医学院第一附属医院胸外科行手术治疗的105例胸段食管鳞状细胞癌患者为研究对象,根据术后是否发生淋巴结转移分为淋巴结转移组(n=34)和非淋巴结转移组(n=71)。收集患者的临床资料,采用单因素和多因素logistic回归分析影响胸段食管鳞状细胞癌患者淋巴结转移的危险因素。结果单因素分析结果显示,胸段食管鳞状细胞癌患者的病理分化程度、肿瘤最大长径、脉管癌栓与淋巴结转移有关(P<0.05);患者的年龄、性别、是否有饮酒史、肿瘤浸润深度、组织病理类型、是否有神经侵犯、肿瘤位置与淋巴结转移无关(P>0.05)。多因素logistic回归分析结果显示,肿瘤最大长径长、分化程度低、有脉管癌栓为胸段食管鳞状细胞癌淋巴结转移的独立危险因素(P<0.05)。结论肿瘤最大长径大、分化程度低、存在脉管癌栓是食管鳞状细胞癌患者出现淋巴结转移的危险因素。Objective To investigate the risk factors for postoperative lymph node metastasis in patients with thoracic esophageal squamous cell carcinoma.Methods A total of 105 patients with esophageal squamous cell carcinoma in the thoracic segment who underwent surgical treatment at the Department of Thoracic Surgery of the First Affiliated Hospital of Xinxiang Medical University from January 2020 to June 2022 were selected as the research subjects.The patients were divided into the lymph node metastasis group(n=34)and the non-lymph node metastasis group(n=71)according to whether lymph node metastasis occurred postoperatively.Clinical data of patients were collected.Risk factors for lymph node metastasis in patients with esophageal squamous cell carcinoma in the thoracic segment were analyzed by using univariate and multivariate logistic regression.Results Univariate analysis showed that the pathologic differentiation grade,maximum tumor length,and vascular cancer embolism were associated with lymph node metastasis in patients with esophageal squamous cell carcinoma in the thoracic segment(P<0.05);the patient′s age,gender,history of drinking,depth of tumor infiltration,histopathological type,nerve invasion status,and tumor location showed no significant correlation with lymph node metastasis(P>0.05).The multivariate logistic regression analysis revealed that larger maximum tumor length,lower differentiation grade,and the presence of vascular cancer emboli were independent risk factors for lymph node metastasis in patients with esophageal squamous cell carcinoma in the thoracic segment(P<0.05).Conclusion Larger maximum tumor length,lower differentiation grade,and the presence of vascular emboli are risk factors for lymph node metastasis in patients with esophageal squamous cell carcinoma.

关 键 词：食管鳞状细胞癌 淋巴结转移 危险因素 

分 类 号：R655.4[医药卫生—外科学]