中药干预人肺腺癌A549细胞的实验研究进展  

Progress of Experimental Research on Intervention of Traditional Chinese Medicine in Human Lung Adenocarcinoma A549 Cells

作　　者：周佳静 张利 侯爱画 崔长磊 严吉峰 ZHOU Jiajing;ZHANG Li;HOU Aihua;CUI Changlei;YAN Jifeng(Dept.of Oncology,Yantai Hospital of Traditional Chinese Medicine,Shandong Yantai 264000,China;the First School of Clinical Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250011,China;Dept.of Clinical Education,Yantai Nurses School of Shandong,Shandong Yantai 264000,China)

机构地区：[1]烟台市中医医院肿瘤科,山东烟台264000 [2]山东中医药大学第一临床医学院,济南250011 [3]山东省烟台护士学校临床教学部,山东烟台264000

出　　处：《中国医院用药评价与分析》2024年第6期764-768,共5页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：山东省自然科学基金青年项目(No.ZR2021QH023);山东省医务职工科技创新计划项目(No.SDYWZGKCJHLH202277)。

摘　　要：恶性肿瘤中,肺癌在国内和世界范围内的发病率、死亡率均居首位。非小细胞肺癌是主要的肺癌类型,而肺腺癌是非小细胞肺癌中常见的病理类型。A549细胞是一种实验用肺癌细胞,常被用于肺腺癌的研究模型。由于中药的低毒、有效、安全等特点,越来越多的研究聚焦于中药治疗肺癌的作用机制。目前,关于中药对肺腺癌A549细胞的实验研究不断开展,笔者经过查阅大量相关文献,将研究分为中药复方和中药单体的干预研究,对其进行综述。Among malignant tumors,lung cancer has the highest morbidity and mortality both domestically and worldwide.Non-small cell lung cancer is the main type of lung cancer,while lung adenocarcinoma is a common pathologic type of non-small cell lung cancer.A549 cells are a type of experimental lung cancer cells commonly used as research models for lung adenocarcinoma.Due to the characteristics of low toxicity,significant efficacy and high safety of traditional Chinese medicine,more and more studies focus on the mechanism of traditional Chinese medicine in the treatment of lung cancer.At present,experimental studies on the effects of traditional Chinese medicine on lung adenocarcinoma A549 cells have been continuously carried out.After reviewing a large amount of relevant literature,the studies are categorized into intervention studies of traditional Chinese medicine compounds and traditional Chinese medicine monomers,which were reviewed.The following is a summary of these studies.

关 键 词：肺腺癌 A549细胞 中药 实验研究 

分 类 号：R965[医药卫生—药理学]