单纯形重心法复配多糖/纳米纤维素水凝胶  

Preparation of Polysaccharide/nanocellulose Hydrogel by Simplex Barycenter Method

作　　者：张紫薇 丛海花 沈益诚 逯晓燕 ZHANG Ziwei;CONG Haihua;SHEN Yicheng;LU Xiaoyan(College of Food Science and Engineering,Dalian Ocean University,Dalian 116023,China;Xiaodongyijian(Suzhou)Instruments and Equipment Co.,Ltd.,Suzhou 215152,China)

机构地区：[1]大连海洋大学食品科学与工程学院,辽宁大连116023 [2]晓东宜健(苏州)仪器设备有限公司,江苏苏州215152

出　　处：《纤维素科学与技术》2024年第2期65-71,共7页Journal of Cellulose Science and Technology

基　　金：辽宁省教育厅高等学校基本科研项目面上项目(LJKZ0715);江苏省高职院校教师专业带头人高端研修项目(2023GRFX061);2022年青年教师科研能力提升计划(BS[2022]18);江苏省高校“青蓝工程”中青年学术带头人项目。

摘　　要：以海藻酸钠(SA)、黄原胶(XAN)、结冷胶(G)和纳米纤维素(NC)为水凝胶壁材,并采用{4,4}单纯形重心法进行试验设计筛选出最佳配方。对水凝胶的形态、质构特性、pH敏感性和傅里叶变换红外光谱进行分析。结果表明,添加NC增加水凝胶共混溶液的黏度,改善了表观形态、增强水凝胶的质构特性;傅里叶变换红外光谱显示NC和多糖之间具有良好的相容性,添加NC后提高水凝胶的膨胀率,复配的多糖/纳米纤维素水凝胶具有良好pH值敏感性。最后通过单纯形重心法得到理论最优组(SA19.25%;XAN24.10%;G41.00%;NC15.23%)。综上所述,最终成功采用单纯形重心法成功复配出具有良好的pH敏感性、稳定通过模拟胃环境的纳米水凝胶,这为复合水凝胶包埋需氧益生菌提供基础数据,且为研究与应用水凝胶递送系统提供了参考。In this study,sodium alginate(SA),xanthan gum(XAN),gelatin(G),and nanocellulose(NC)were utilized as encapsulating materials.The simplex barycenter method was employed to optimize the formulation through experimental design.The morphology,texture properties,pH sensitivity and Fourier transform infrared spectroscopy(FT-IR)of the hydrogels were analyzed.The results indicated that the addition of NC increased the viscosity of the hydrogel blend solution,improved the apparent morphology and enhanced the textural properties of the hydrogel,FT-IR showed good compatibility between NC and the polysaccharides.Furthermore,the inclusion of NC increased the swelling ratio of the hydrogel.The polysaccharide/nanocellulose composite hydrogel exhibited excellent pH sensitivity.The theoretical optimal composition was obtained through the simplex barycenter method(SA 19.25%;XAN 24.10%;G 41.00%;NC 15.65%).In conclusion,the final work used the simplex barycenter method to prepare the nanogel with excellent pH sensitivity,capable of stable passage through simulated gastric environments.This provides foundational data for the encapsulation of aerobic probiotics in composite hydrogels and offers a reference for further research and application of hydrogel delivery systems.

关 键 词：多糖基复合水凝胶 PH敏感性 单纯形重心法 理化性质 

分 类 号：R318.08[医药卫生—生物医学工程]