掺氮碳量子点用于柳氮磺吡啶的快速检测  

Rapid Detection of Sulfasalazine Using a Nitrogen-doped Carbon Quantum Dots

作　　者：赵艳[1] 孙雪花[2] ZHAO Yan;SUN Xue-hua(Medical College,Yan’an University,Yan’an 716000,China;Key Lab of Chemical Reaction Engineering of Shaanxi Province,College of Chemistry and Chemical Engineering,Yan’an University,Yan’an 716000,China)

机构地区：[1]延安大学医学院,陕西延安716000 [2]陕西省化学反应工程重点实验室,延安大学化学化工学院,陕西延安716000

出　　处：《分析测试学报》2024年第7期1052-1057,共6页Journal of Instrumental Analysis

基　　金：国家自然科学基金项目(22063010);陕西省自然科学基金项目(2022QFY07-05);延安大学校级大学生创新项目(D2023172)。

摘　　要：以微波法一步合成制备出荧光性能强、荧光量子产率为89.38%的掺氮碳量子点(N-CDs),并通过荧光猝灭法建立了快速准确测定柳氮磺吡啶(SSZ)的新方法。通过透射电子显微镜、傅里叶红外光谱对碳量子点进行表征,结果显示N-CDs的平均粒径为2.91 nm,主要由C、O、N元素组成,大量羰基、羟基和羧基存在于N-CDs表面。在最佳条件下,柳氮磺吡啶浓度在0.1~2μmol/L和3~200μmol/L范围内线性良好,检出限为0.2μmol/L。将所建方法用于柳氮磺吡啶肠溶片中柳氮磺吡啶含量的测定,回收率为97.3%~102%。The nitrogen-doped carbon quantum dots(N-CDs)with high fluorescence properties and fluorescence quantum yield of 89.38%were prepared by microwave one-step synthesis.A new meth⁃od for the rapid and accurate determination of sulfasalazine(SSZ)was established by fluorescence quenching.The carbon quantum dots were characterized by transmission electron microscopy(TEM)and Fourier infrared spectroscopy(FT-IR).The results showed that the average particle size of NCDs was 2.91 nm,mainly composed of C,O and N elements,and a large number of carbonyl,hy⁃droxyl and carboxyl groups existed on the surface of N-CDs.Under the optimal conditions,the con⁃centration of sulfasalazine was linear in the range of 0.1-2μmol/L and 3-200μmol/L,and the de⁃tection limit was 0.2μmol/L.The content of sulfasalazine in sulfasalazine enteric-coated tablets was determined by this method,and the recovery was 97.3%-102%.

关 键 词：微波法 掺氮碳量子点 荧光猝灭 柳氮磺吡啶 

分 类 号：O657.3[理学—分析化学] R978.2[理学—化学]