调胃承气汤治疗脑梗死急性期胃肠功能障碍临床研究  

Clinical Study on the Treatment of Gastrointestinal Dysfunction During the Acute Phase of Cerebral Infarction using Tiaowei Chengqi Decoction

作　　者：刘欢欢 葛辰轩 颜晓晗 安朋朋 张增 王春燕[1] 唐明 LIU Huanhuan;GE Chenxuan;YAN Xiaohan;AN Pengpeng;ZHANG Zeng;WANG Chunyan;TANG Ming(Shandong University of Traditional Chinese Medicine,Shandong Ji’nan 250014,China;Tai’an Hospital of Traditional Chinese Medicine,Shandong Taian 271001,China;Qingdao Hospital of Traditional Chinese Medicine,Shandong Qingdao 266033,China)

机构地区：[1]山东中医药大学,山东济南250014 [2]泰安市中医医院,山东泰安271001 [3]青岛市中医医院,山东青岛266033

出　　处：《中医药临床杂志》2024年第6期1120-1123,共4页Clinical Journal of Traditional Chinese Medicine

基　　金：青岛市卫生和计划生育委员会民生科技计划(18-6-1-69-nsh)。

摘　　要：目的:观察调胃承气汤对脑梗死急性期胃肠功能障碍的临床疗效。方法:60例脑梗死急性胃肠功能障碍患者随机分为对照组和观察组,两组接受西医常规治疗,观察组在西医常规治疗基础上给予调胃承气汤颗粒口服,疗程为1周,观察记录治疗前后NIHSS评分、胃肠功能障碍评分、中医证候评分;血清胃动素和瓜氨酸水平,并观察不良反应。结果:治疗后两组患者NIHSS评分、胃肠功能障碍评分、中医证候评分、胃动素和瓜氨酸水平均较治疗前有改善(P<0.05);治疗后,观察组对于NIHSS评分、胃肠功能障碍评分、中医证候评分、瓜氨酸水平改善程度优于对照组(P<0.05);观察组对于胃动素水平改善程度与对照组差异无统计学意义(P>0.05)。结论:调胃承气汤可以改善脑梗死急性期胃肠功能障碍患者的急性胃肠损伤,降低胃动素水平,提高瓜氨酸水平,改善胃肠道不良症状,促进患者神经功能恢复,提高患者预后水平。Objective:To observe the clinical efficacy of Tiaowei Chengqi Decoction on gastrointestinal dysfunc-tion in the acute phase of cerebral infarction.Methods:60 patients with acute gastrointestinal dysfunction after cerebral infarction were randomly divided into a control group and an observation group.The two groups received conventional Western medicine treatment.The observation group was given oral Tiaowei Chengqi decoction granules on the basis of conventional Western medicine treatment.The course of treatment was 1 week.,observe and record the NIHSS score,gastrointestinal dysfunction score,and traditional Chinese medicine syndrome score before and after treatment;serum motilin and citrulline levels,and observe adverse reactions.Results:After treatment,the NIHSS scores,gastrointesti-nal dysfunction scores,traditional Chinese medicine syndrome scores,motilin and citrulline levels of the two groups of patients were improved after treatment(P<0.05);after treatment,the observation group had better NIHSS scores,The improvement degree of gastrointestinal dysfunction score,traditional Chinese medicine syndrome score,and citrulline level was better than that of the control group(P<0.05);there was no statistically significant difference in the improve-ment degree of motilin level between the observation group and the control group(P>0.05).Conclusion:Tiaowei Cheng-qi Decoction can improve acute gastrointestinal injury in patients with gastrointestinal dysfunction in the acute phase of cerebral infarction,reduce motilin levels,increase citrulline levels,improve gastrointestinal adverse symptoms,promote the recovery of patients’neurological function,and improve patient prognosis level.

关 键 词：调胃承气汤 脑梗死 胃肠功能障碍 胃动素 瓜氨酸 

分 类 号：R256.3[医药卫生—中医内科学]