加味升陷汤联合常规治疗对慢性心力衰竭患者心功能及血清同型半胱氨酸高敏肌钙蛋白T影响  

Effects of Modified Shengjin Decoction Combined with Conventional Treatment on Cardiac Function and Serum Hcy and hsTnT in Patients with Chronic Heart Failure

作　　者：谷雪军 邹文庆 邹佳辰 GU Xuejun;ZOU Wenqing;ZOU Jiachen(Henan Shangqiu City Hospital of Traditional Chinese Medicine,Henan Shangqiu 476000,China)

机构地区：[1]河南省商丘市中医院,河南商丘476000

出　　处：《中医药临床杂志》2024年第6期1124-1128,共5页Clinical Journal of Traditional Chinese Medicine

摘　　要：目的:分析加味升陷汤辅助西医常规治疗慢性心力衰竭(Chronic heart failure,CHF)的疗效及对患者心功能及心肌损伤指标、炎症相关指标的影响。方法:以1:1随机信封方法河南商丘市中医院2022年4月—2023年4月接收的150例CHF患者分为对照组、研究组,各75例。对照组予以西医常规治疗,研究组在此基础上加用加味升陷汤治疗。治疗4周后,比较两组疗效,心功能左室射血分数,左心室舒张末经,心搏出量,心脏指数。心肌损伤指标:N末端脑钠肽前体,同型半胱氨酸,高敏肌钙蛋白T。炎症相关指标:基金蛋白酶2,可溶性ST2蛋白,生长分化因子-15及不良反应。结果:研究组总有效率(97.33%)高于对照组(86.67%)(P<0.05);治疗后研究组左室射血分数、心搏出量、心脏指数高于对照组,左心室舒张末经低于对照组(P<0.05);治疗后研究组N末端脑钠肽前体、同型半胱氨酸、高敏肌钙蛋白T低于对照组(P<0.05);治疗后研究组基金蛋白酶2,可溶性ST2蛋白,生长分化因子-15低于对照组(P<0.05);两组不良反应总发生率分别为研究组5.33%、对照组8.00%,相比差异无统计学意义(P>0.05)。结论:加味升陷汤联合西医治疗CHF效果确切,可减轻炎症反应,减少心肌损伤,改善心功能,方案较安全。Objective: To analyze the efficacy of Modified Shengxian Decoction in assisting conventional Western medicine in the treatment of chronic heart failure (CHF) and its impact on patients’ cardiac function, myocardial dam-age indicators, and inflammation-related indicators. Methods: 150 CHF patients received by Henan Shangqiu Tradi-tional Chinese Medicine Hospital from April 2022 to April 2023 were divided into a control group and a research group, with 75 cases in each group, using a 1:1 random envelope method. The control group received conventional Western medicine treatment, and the research group received modified Shengxian Decoction in addition to this. After 4 weeks of treatment, the efficacy, cardiac function, left ventricular ejection fraction, left ventricular end-diastolic meridian, stroke volume, and cardiac index were compared between the two groups. Myocardial injury indicators: N-terminal brain natriuretic peptide precursor, homocysteine, high-sensitivity troponin T. Inflammation-related indicators: fundase 2, soluble ST2 protein, growth differentiation factor-15 and adverse reactions. Results: The total effective rate of the study group (97.33%) was higher than that of the control group (86.67%) (P<0.05);after treatment, the left ventricular ejec-tion fraction, cardiac output, and cardiac index of the study group were higher than those of the control group, and the left ventricular diastole was The end of menstruation was lower than that in the control group (P<0.05);after treatment, the N-terminal brain natriuretic peptide precursor, homocysteine, and high-sensitivity troponin T in the research group were lower than those in the control group (P<0.05);after treatment, the research group’s fund Protease 2, soluble ST2 protein, and growth differentiation factor-15 were lower than those in the control group (P<0.05);the total incidence of adverse reactions in the two groups were 5.33% in the study group and 8.00% in the control group, with no statisti-cally significant difference (P>0.05). Conclusi

关 键 词：加味升陷汤 慢性心力衰竭 心功能 心肌损伤 炎症 

分 类 号：R259[医药卫生—中西医结合]