半夏泻心汤联合四联疗法治疗慢性萎缩性胃炎癌前病变疗效分析  

Analysis of the Therapeutic Effect of Banxia Xiexin Decoction Combined with Qua druple Therapy in the Treatment of Precancerous Lesions in Chronic Atrophic Gastritis

作　　者：吕安定 杜囚鹏 景竹春 LYU Anding;DU Prisoner Peng;JING Zhuchun(Dongba District Preventive Medicine Department of Beijing First Traditional Chinese and Western Medicine Hospital,Beijing 100018,China)

机构地区：[1]北京市第一中西医结合医院东坝院区,北京100018

出　　处：《中医药临床杂志》2024年第6期1139-1143,共5页Clinical Journal of Traditional Chinese Medicine

基　　金：中国中医药研究促进会科研立项(2022063)。

摘　　要：目的:观察半夏泻心汤联合四联疗法治疗慢性萎缩性胃炎癌前病变的临床疗效。方法:采用随机数字表法将北京市第一中西医结合医院东坝院区2020年12月—2023年12月收治的慢性萎缩性胃炎癌前病变患者160例分为两组各80例。对照组采用四联疗法治疗,观察组在对照组基础上加用半夏泻心汤加味汤治疗,两组均治疗2周。比较两组治疗后临床疗效,治疗前后中医证候评分、胃泌素-17(G-17)、胃蛋白酶Ⅰ(PG-Ⅰ)、胃蛋白酶Ⅱ(PG-Ⅱ)、病理组织评分。结果:治疗后,观察组总有效率高于对照组(P<0.05);两组中医证候评分、病理组织评分、PG-Ⅰ、PG-Ⅱ均低于治疗前(P<0.05),试验组均低于对照组(P<0.05);两组G-17均高于治疗前(P<0.05),试验组高于对照组(P<0.05);试验组Hp根除率高于对照组(P<0.05)。结论:半夏泻心汤联合四联疗法治疗慢性萎缩性胃炎癌前病变可改善临床证候,调节胃泌素、胃蛋白酶分泌,修复受损胃黏膜组织,有助于胃炎病理改变逆转,促进Hp转阴,提高总有效率,值得推广。Objective: To observe the clinical efficacy of Banxia Xiexin Decoction combined with Quadruple Therapy in the treatment of precancerous lesions in chronic atrophic gastritis.Method: 160 patients with precancerous lesions of chronic atrophic gastritis from December 2020 to December 2023 admitted to the Dongba campus of Beijing First Tra-ditional Chinese and Western Medicine Hospital were randomly divided into two groups using a random number table method, with 80 cases in each group.The control group received quadruple therapy, while the observation group re-ceived treatment with Banxia Xiexin Decoction and Jiawei Decoction in addition to the control group.They were treated for 2 weeks,compare the clinical efficacy, traditional Chinese medicine syndrome score, pathological tissue score, gastrin-17 (G-17), PG-I and PG-Ⅱ.Result: After treatment,the total effective rate of the observation group was higher(P<0.05).The TCM syndrome scores,pathological tissue score,PG-I and PG-Ⅱ of both groups were lower than before treatment (P<0.05), and the experimental group were lower(P<0.05),both groups of G-17 levels were higher than before treatment (P<0.05), while the experimental group was higher(P<0.05),the Hp eradication rate in the experimental group was higher(P<0.05).Conclusion: Banxia Xiexin Decoction can improve the treatment effect,and clinical symptoms, regulate the secretion of gastrin and pepsinogen, repair damaged gastric mucosal tissue, and help reverse pathological changes in gastritis,promote Hp to turn negative,it is worth promoting.

关 键 词：慢性萎缩性胃炎 癌前病变 四联疗法 半夏泻心汤 

分 类 号：R259[医药卫生—中西医结合]