清肾颗粒联合中药保留灌肠治疗非透析慢性肾脏病疗效观察  

Curative Effect of Qingshen Granule Combined with Chinese Medic ine Retention Enema on Non-Dialysis Chronic Kidney Disease

作　　者：管婷婷 王东[2] 吕勇[2] 王亿平[2] GUAN Tingting;WANG Dong;LYU Yong;WANG Yiping(The First Clinical Medical College of Anhui University of Traditional Chinese Medicine,Anhui Hefei 230022,China;The First Affiliated Hospital of Anhui University of Chinese Medicine,Anhui Hefei 230031,China)

机构地区：[1]安徽中医药大学第一临床医学院,安徽合肥230022 [2]安徽中医药大学第一附属医院,安徽合肥230031

出　　处：《中医药临床杂志》2024年第6期1154-1157,共4页Clinical Journal of Traditional Chinese Medicine

基　　金：2021年安徽省级医疗卫生重点专科建设项目(皖卫函[2021]273号);第七批全国老中医药专家学术经验继承项目(国中医药人教函[2022]76号);全国名老中医药专家曹恩泽传承工作室建设项目(国中医药人教函[2022]245号);2023安徽省自然科学基金面上项目(2308085MH292)。

摘　　要：目的:观察清肾颗粒联合中药保留灌肠对非透析慢性肾脏病(CKD)3~5期患者的疗效,并探究其对患者营养状况及钙磷水平的影响。方法:采用清肾颗粒联合黄苓解毒泄浊颗粒保留灌肠治疗非透析CKD 3~5期患者,并设对照组和治疗组,观察临床疗效以及中医证候积分、营养状况改善情况(血清白蛋白、血红蛋白)、钙磷代谢情况(钙、磷等)指标。结果:治疗组和对照组的临床疗效分别为67.5%(27/40)和35%(14/40),治疗组疗效显然胜于对照组(P<0.05);且与对照组比较,治疗组的营养状态和钙磷代谢都有了显著的提高,具有显著的差异。(P<0.05)。结论:清肾颗粒结合中药保留灌肠能缓解非透析CKD 3~5期患者的临床症状,改善其营养状况和钙磷水平,提高临床疗效。Objective:To observe the efficacy of Qingshen granules combined with traditional Chinese medicine retention enema in patients with non-dialysis chronic kidney disease(CKD)stage 3-5,and to explore its impact on patients’nutritional status and calcium and phosphorus levels.Methods:Qingshen granules combined with Huangling Jiedu Xiezhuo granules and retention enema were used to treat non-dialysis CKD stage 3-5 patients,and a control group and a treatment group were set up to observe the clinical efficacy,TCM syndrome scores,and nutritional status improvement(serum albumin,hemoglobin),calcium and phosphorus metabolism(calcium,phosphorus)and other indi-cators.Results:The clinical efficacy of the treatment group and the control group were 67.5%(27/40)and 35%(14/40)respectively.The efficacy of the treatment group was obviously better than that of the control group(P<0.05);and com-pared with the control group,the treatment The nutritional status and calcium and phosphorus metabolism of the group have been significantly improved,with significant differences(P<0.05).Conclusion:Qingshen granules combined with traditional Chinese medicine retention enema can relieve the clinical symptoms of non-dialysis CKD stage 3-5 pa-tients,improve their nutritional status and calcium and phosphorus levels,and improve clinical efficacy.

关 键 词：慢性肾脏病 清肾颗粒 中药保留灌肠 营养状况 钙磷代谢 

分 类 号：R256.51[医药卫生—中医内科学]