早发冠心病发病机制与预防的研究进展  

Research progress on pathogenesis and prevention of premature coronary heart disease

作　　者：张晏铭 于高修 王聪 陈峰 ZHANG Yanming;YU Gaoxiu;WANG Cong;CHEN Feng(Naval Medical University Graduate School,Shanghai 200433,China;Department of Cardiology,The First Hospital Affiliated to Naval Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学研究生院,上海200433 [2]海军军医大学第一附属医院心内科,上海200433

出　　处：《中国临床医学》2024年第3期491-498,共8页Chinese Journal of Clinical Medicine

基　　金：海军军医大学青年培育项目(2023QN061);海军军医大学第一附属医院青年培育项目(2021JCQN15)。

摘　　要：冠心病传统危险因素包括高血压、糖尿病、血脂异常和高胆固醇血症、肥胖与超重、嗜烟、嗜酒等。冠心病发病率逐年升高,且患者呈年轻化趋势。美国胆固醇成人治疗组教育计划第3次指南(NCEP ATP-Ⅲ)将早发冠心病(PCHD)定义为冠心病发病年龄在男性小于55岁、女性小于65岁。PCHD目前已成为国内外研究热点。除控制冠心病的传统危险因素外,通过探讨PCHD新的发病机制及预测因素以做好其一级预防也很重要。本文对近年来国内外相关临床与基础研究结论进行总结,旨在探讨PCHD的最新发病机制和相关预测因素,为其临床一级预防提供参考。The conventional risk factors associated with coronary heart disease(CHD)include hypertension,diabetes mellitus,dyslipidemia and hypercholesterolemia,obesity and overweight,smoking and alcohol consumption,etc..The incidence of CHD has increased year by year,and a discernible shift towards a younger age of onset is evident.“The third report of the national cholesterol education program adult treatment panelⅢ”(NCEP ATP-Ⅲ)defines premature CHD(PCHD)as manifestation in males<55 years and females<65 years.At recently,PCHD has emerged as a focal point in both domestic and international study.In addition to the established risk factors,there is a important need to elucidate novel pathogenic mechanisms and predictive factors governing PCHD.This necessitates concerted efforts in primary prevention.This manuscript conducts a comprehensive review of antecedent researches,with the primary objective of discussing the latest pathogenic mechanisms and predictive factors associated with PCHD.The reviewing aim is to contribute substantive insights to the primary prevention of PCHD.

关 键 词：早发冠心病 发病机制 一级预防 微血管功能 预测因素 

分 类 号：R541.4[医药卫生—心血管疾病]