整合毒理学:一种有效阐释中药之“毒”的解决方案  

Integrated toxicology:an effective solution for explaining the“Toxicity”of traditional Chinese medicine

作　　者：徐焕华 周维 易剑锋 张伯礼[5] 高月 Huanhua Xu;Wei Zhou;Jianfeng Yi;Boli Zhang;Yue Gao(Key Laboratory of Modern Preparation of TCM,Ministry of Education,Jiangxi University of Chinese Medicine,Nanchang,China;National Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine,Jiangxi University of Chinese Medicine,Nanchang,China;Department of Pharmaceutical Sciences,Beijing Institute of Radiation Medicine,Beijing,China;Research Center for Differentiation and Development of Traditional Chinese Medicine Basic Theory,Jiangxi University of Chinese Medicine,Nanchang,China;Tianjin University of Traditional Chinese Medicine,Tianjin,China)

机构地区：[1]江西中医药大学现代中药制剂教育部重点实验室,南昌330004 [2]江西中医药大学经典名方现代中药创制全国重点实验室,南昌330004 [3]军事科学院军事医学研究院辐射医学研究所,北京100850 [4]江西中医药大学中医基础理论分化发展研究中心,南昌330004 [5]天津中医药大学,天津301617

出　　处：《Acupuncture and Herbal Medicine》2024年第2期167-170,I0003,I0004,共6页针灸和草药（英文）

基　　金：financially supported by the National Nature Science Foundation of China (82304857);Jiangxi Provincial Natural Science Foundation (20224BAB216105,20232BAB206167);the National Nature Science Foundation of China (82192910)。

摘　　要：中药的安全性问题已经成为中医药行业发展的瓶颈,严重制约中医药的现代化和国际化。重新审视中药对“毒”的理解并进一步发展现代中药毒理学迫在眉睫。中药因其自身特性,其安全性研究与现代毒理学(西方毒理学)相比存在较大差异,且具备如下特点:毒性发生的隐匿性、物质基础的不确定性、安全剂量的模糊性、毒-效机制的复杂性、个体差异的特殊性。由此也引申出中药安全性研究面临的一些关键科学问题,例如“有毒”中药与机体互作后如何产生毒性?配伍后如何减毒?针对上述关键科学问题,基于在中药安全性领域的多年实践,高月研究员团队率先在本文中提出中药整合毒理学研究理念。整合毒理学,即中药学、替代毒理学、药理学、计算科学、中药化学、分子生物学等多学科交叉融通,用以研究复杂体系与机体相互作用及其减毒配伍规律的一门交叉学科。以此理念为指导,研究团队在本文中展示了补骨脂毒性新机制发现及复方黄黛片减毒配伍新科学内涵阐释两项研究范例。整合毒理学研究理念的提出及应用,有利于克服中药的毒性孤岛评价,形成具有中药特色的毒理学评价体系和研究方法,是一种行之有效的、能阐释中药之“毒”内涵的解决方案。Conceptualization of“Toxicity”in traditional Chinese medicine(TCM)In this evolving era,there is an increasing demand for superior-grade TCM products.However,a spate of safety incidents related to Chinese herbal medicines in recent years has garnered considerable scrutiny and concern[1],both nationally and globally.These safety concerns[2]have emerged as critical impediments in the advancement of the TCM industry,markedly constrain-ing the modernization and globalization efforts of TCM practices.A reassessment and delicate understanding of the concept of“toxicity”related to TCM coupled with advancement of contemporary TCM toxicology are now recognized as imperative strategies to effectively address these challenges[3,4].

关 键 词：中药安全性 医药行业发展 毒理学评价 安全剂量 中药化学 配伍规律 减毒 中药学 

分 类 号：R285[医药卫生—中药学]