补骨脂对肝脏的双重作用:肝保护还是肝毒性?  

Dual effects of Psoraleae Fructus on the liver:hepatoprotection or hepatoxicity?

作　　者：唐千茴 俞沁纬 Bin Ni 江振洲[1,3] 张陆勇 Qianhui Tang;Qinwei Yu;Bin Ni;Zhenzhou Jiang;Luyong Zhang(New Drug Screening and Pharmacodynamics Evaluation Center,State Key Laboratory of Natural Medicines,China Pharmaceutical University,Nanjing,China;Alliance Pharma,Malvern,PA,USA;Key Laboratory of Drug Quality Control and Pharmacovigilance,Ministry of Education,China Pharmaceutical University,Nanjing,China;Center for Drug Research and Development,Guangdong Pharmaceutical University,Guangzhou,China)

机构地区：[1]中国药科大学多靶标天然药物全国重点实验室新药筛选与药效评价中心,南京 [2]Alliance Pharma,Malvern,PA USA [3]中国药科大学药物质量与安全预警教育部重点实验室,南京 [4]广东药科大学新药研发中心,广州

出　　处：《Acupuncture and Herbal Medicine》2024年第2期176-183,I0005,共9页针灸和草药（英文）

基　　金：supported by the National Natural Science Foundation of China (81320108029);the National “Major Scientific and Technological Special Project for Significant New Drugs” project (2015ZX09501004-002-004);Specific Fund for Public Interest Research of Traditional Chinese Medicine,Ministry of Finance (201507004-002)。

摘　　要：中药补骨脂(Psoraleae Fructus)为豆科植物补骨脂Psoralea corylifolia L.的干燥成熟果实,主要包含黄酮、香豆素、单萜酚和苯并呋喃类化合物,具有免疫调节、抗氧化、雌激素样等多种药理作用,临床广泛应用于治疗骨质疏松、白癜风、银屑病等。目前,越来越多的药理研究表明,补骨脂及其活性成分在肝脏疾病以及动物模型中具有保护肝细胞、改善肝功能的作用;但随着补骨脂及其相关制剂的临床广泛应用,以及药物不良反应监测体系的完善,补骨脂及其相关制剂引发肝脏损伤的不良反应案例报道越来越多,提示补骨脂及其相关制剂对肝脏可能具有双重作用,即既具有肝脏保护作用又具有肝毒性作用。本文总结了近年来有关补骨脂中单体成分、提取物及其相关制剂的肝保护以及肝毒性作用的研究,归纳了其直接肝毒性及其在不同病理条件下对肝脏的毒/效作用及机制,以期为补骨脂及其相关制剂临床适应症的开发以及安全应用提供理论依据。Psoraleae Fructus,the dried mature fruit of the leguminous plant Psoralea corylifolia L.,contains flavonoids,coumarins,monoterpene phenols,and benzofurans.It exhibits various pharmacological activities,including immune regulation,antioxidant properties,photosensitivity,and estrogen-like effects,and finds extensive use in the clinical treatment of osteoporosis,vitiligo,and psoriasis.Extensive pharmacological research has demonstrated that Psoraleae Fructus and its components improve liver function and protect hepatocytes in animal and cellular models of liver diseases.Moreover,with the increasing clinical applications of Psoraleae Fructus and its derivatives,as well as the progression in adverse drug reaction surveillance,there is an increase in clinical cases involving these preparations and the enhancement of monitoring for any adverse reactions linked to Psoraleae Fructus and its related compounds.Here,we examined the hepatoprotective effects and hepatotoxicity of the monomer components,extracts,and related preparations of Psoraleae Fructus.We aim to contribute to safety evaluation,facilitate informed clinical application,and foster advancements in Psoraleae Fructus and its derivatives.

关 键 词：药物性肝损伤 肝保护 肝毒性 补骨脂 

分 类 号：R285[医药卫生—中药学]