TGF-β信号通路在骨髓增生异常综合征中作用机制的研究进展  

Research progress on the mechanism of the TGF-βsignaling pathway in myelodysplastic syndrome

作　　者：刘青青 李宜蔷 石玉士 陆海颂[2] 程纬民[2] LIU Qingqing;LI Yiqiang;SHI Yushi;LU Haisong;CHENG Weimin(Graduate School of Guangxi University of Traditional Chinese Medicine,Nanning 530001,China;Department of Hematology,First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine)

机构地区：[1]广西中医药大学研究生学院,530001 [2]广西中医药大学第一附属医院血液内科

出　　处：《天津医药》2024年第7期781-784,共4页Tianjin Medical Journal

基　　金：广西中医药管理局资助项目(GZZC2019058)。

摘　　要：骨髓增生异常综合征(MDS)是一种细胞遗传学与分子遗传学高度异质性的恶性克隆性疾病,且进展为急性髓系白血病(AML)的风险极高。转化生长因子-β(TGF-β)与MDS的发病密切相关,是免疫稳态及免疫耐受的关键执行者,可抑制免疫系统许多组成部分的扩张和功能。TGF-β信号通路能调控微环境中的造血细胞及免疫细胞,抑制其发挥正常生物学功能,从而加快MDS的疾病进展。就近年来TGF-β信号通路对MDS红细胞、T淋巴细胞、自然杀伤细细胞、巨噬细胞的调控作用进行综述,以期为MDS的发病机制及治疗提供新的视角。Myelodysplastic syndrome(MDS)is a malignant clonal disease with high heterogeneity in cytogenetics and molecular genetics,and the risk of progression to acute myeloid leukemia(AML)is extremely high.Transforming growth factor-β(TGF-β)is closely related to the pathogenesis of MDS.It is a key executor of immune homeostasis and immune tolerance,and can inhibit the expansion and function of many components of immune system.TGF-βsignaling pathway can regulate hematopoietic cells and immune cells in microenvironment,inhibit their normal biological functions,and thus accelerate the progression of MDS.This study reviews regulatory effects of TGF-βsignaling pathway on MDS blood cells,T lymphocytes,natural killer cells and macrophages in recent years,and provides a new perspective for the pathogenesis and treatment of MDS.

关 键 词：骨髓增生异常综合征 转化生长因子Β 信号传导 免疫细胞 作用机制 

分 类 号：R552[医药卫生—血液循环系统疾病]