苯磺酸瑞马唑仑对妇科手术患者注射痛的影响  

Effect of remazolam besylate on injection pain in gynecological surgery patients

作　　者：张先杰[1] 蒋文才 郭红利 廖欧 韩佳[1] ZHANG Xianjie;JIANG Wencai;GUO Hongli;LIAO Ou;HAN Jia(Department of Anesthesia,Deyang People's Hospital,Deyang 618000,China;Department of Anesthesia,Deyang Fifth Hospital,Deyang 618000,China)

机构地区：[1]德阳市人民医院麻醉科,四川德阳618000 [2]德阳第五医院麻醉科,四川德阳618000

出　　处：《长春中医药大学学报》2024年第7期783-786,共4页Journal of Changchun University of Chinese Medicine

基　　金：四川省科技项目(2019YJ0700)。

摘　　要：目的观察苯磺酸瑞马唑仑预处理对妇科门诊无痛手术患者丙泊酚注射痛的影响。方法选取德阳市人民医院2022年7月1日-2023年1月31日妇科门诊收治拟行门诊无痛手术的患者301例作为研究对象。按随机数字表法分为苯磺酸瑞马唑仑镇静组(R组)、咪达唑仑镇静组(M组),其中R组146例,M组155例。R组诱导前给予苯磺酸瑞马唑仑注射液;M组诱导前给予常规镇静药物咪达唑仑注射液。观察2组诱导后不同时间点基础生命体征变化、注射痛的发生率、麻醉效果、补救镇静率及不良反应发生率。结果同M组相比,R组血流动力学更稳定,注射痛发生率显著减少,全麻药丙泊酚用量更少,麻醉效果更好,补救镇静次数及不良反应发生率显著降低。结论苯磺酸瑞马唑仑预处理可有效降低妇科门诊无痛手术患者丙泊酚注射痛的发生率,减少术中丙泊酚总用量及缩短术后患者苏醒时间,并能维持血流动力学稳定,更加安全有效。Objective To observe the effect of remazolam besylate pretreatment on propofol injection pain in gynecological outpatients undergoing painless surgery.Methods 301 patients who planned to undergo painless surgery in gynecology clinic of Deyang People's Hospital from July 1,2022 to January 31,2023 were selected as the research subjects and divided into remazolam besylate group(group R)(n=146)and midazolam group(group M)(n=155)according to random number table method.Before induction,group R received remazolam besylate injection,while group M received midazolam injection.The changes of basic vital signs,the incidence of injection pain,anesthesia effect,salvage sedation rate,and incidence of adverse reactions at different time points after induction in two groups were observed.Results Compared with group M,in group R,the hemodynamics was more stable,the incidence of injection pain was reduced,the dosage of general anesthesia propofol was less,the anesthesia effect was better,and the frequency of salvage sedation and the incidence of adverse reactions were significantly reduced.Conclusion Remazolam besylate pretreatment can effectively reduce the incidence of propofol injection pain in patients undergoing painless surgery in gynecology clinic,reduce the total dosage of propofol during operation,shorten postoperative recovery time,and maintain hemodynamic stability.This method is safer and more effective.

关 键 词：苯磺酸瑞马唑仑 丙泊酚 注射痛 妇科 无痛 

分 类 号：R614[医药卫生—麻醉学]