儿童结核病中靶向药物治疗的现状和研究进展  

Current status and research progress in targeted drug therapy for pediatric tuberculosis

作　　者：陈秋霞 霍开明[1] CHEN Qiuxia;HUO Kaiming(Department of Paediatrics,the Second Affiliated Hospital of Hainan Medical University,Haikou 570100,China)

机构地区：[1]海南医学院第二附属医院儿科,海口570100

出　　处：《长春中医药大学学报》2024年第7期812-817,共6页Journal of Changchun University of Chinese Medicine

基　　金：海南省卫生健康行业科研项目(20A200095)。

摘　　要：儿童结核病表现为全球重大公共健康问题,特别是其多药耐药形式。与成年结核病相比,儿童因免疫系统特性,对结核菌更为敏感,容易发展为活动性疾病。针对儿童结核病的临床特点、现行治疗方法及靶向药物治疗的发展现状和挑战进行了分析研究。强调了靶向药物治疗在儿童结核病管理中的重要性,不仅能提高治疗效果,还可减少副作用和抗药性问题。同时,讨论了现有治疗策略面临的挑战,如药物剂量优化和长期影响评估,提出了未来研究方向,包括个体化治疗和精准医疗的发展。Childhood tuberculosis is the major global public health issue,especially in its multidrug resisitance forms.Compared with adult tuberculosis,children are more susceptible to Mycobacterium tuberculosis due to the unique characteristics of their immune systems,which makes them more prone to developing active disease.This article analyzes and studies the clinical characteristics,current treatment approaches,and the state of development and challenges of targeted drug treatments for children with tuberculosis.In this paper,the importance of targeted drug treatment in the management of childhood tuberculosis is emphasized,which can not only improve treatment effect,but also reduce side effects and drug resistance.At the same time,this article discusses the challenges facing current treatment strategies,such as optimization of drug dosages and assessment of long-term impacts,and proposes future research directions,including the development of personalized treatment and precision medicine.

关 键 词：儿童结核病 多药耐药结核病 靶向药物治疗 临床特点 治疗策略 

分 类 号：R529.9[医药卫生—内科学]