鱼腥草滴眼液雾化联合睑板腺按摩治疗MGD型干眼的临床疗效  

Clinical Efficacy of Houttuynia Cordata Eye Drops Nebulization Combined with Mei⁃bomian Gland Massage in Treating Meibomian Gland Dysfunction-related Dry Eye

作　　者：路永珩 张永康 LU Yongheng;ZHANG Yongkang(Beijing Huairou Hospital of Traditional Chinese Medicine,Beijing 101400,China)

机构地区：[1]北京市怀柔区中医医院,北京101400

出　　处：《中国中医眼科杂志》2024年第7期622-626,共5页China Journal of Chinese Ophthalmology

摘　　要：目的观察鱼腥草滴眼液超声雾化联合睑板腺按摩治疗睑板腺功能障碍(MGD)型干眼的临床疗效。方法纳入2022年1月—2022年12月北京市怀柔区中医医院诊治的MGD型干眼患者160例(160只眼),证属肝经郁热证,随机分为对照组和观察组,每组80例(80只眼),均选取右眼入组。对照组予睑板腺按摩联合0.1%玻璃酸钠滴眼液点眼。观察组在对照组的基础上联合鱼腥草滴眼液雾化。2组均治疗4周。分别于治疗前和治疗后检测受试者的临床症状积分、眼表疾病指数(OSDI)评分、泪膜破裂时间(BUT)、泪液分泌试验(SⅠT)和泪河高度(LTMH)。结果2组治疗前临床症状积分、OSDI评分、BUT、SⅠT和LTMH比较,差异均无统计学意义(P>0.05)。(1)临床症状积分:2组治疗后临床症状积分均较治疗前降低,差异均有统计学意义(t_(观察组)=18.441、t_(对照组)=9.932,均P=0.000)。治疗后2组间比较,观察组临床症状积分低于对照组,差异有统计学意义(t=2.315,P=0.022)。(2)OSDI评分:2组治疗后OSDI评分均较治疗前降低,差异均有统计学意义(t_(观察组)=15.043、t_(对照组)=16.841,均P=0.000)。治疗后2组间比较,观察组OSDI评分低于对照组,差异有统计学意义(t=3.240,P=0.001)。(3)BUT:2组治疗后BUT均较治疗前延长,差异均有统计学意义(t_(观察组)=14.272、t_(对照组)=12.071,均P=0.000)。治疗后2组间比较,观察组BUT长于对照组,差异有统计学意义(t=4.421,P=0.000)。(4)SⅠT:2组治疗后SⅠT均较治疗前延长,差异均有统计学意义(t_(观察组)=18.611、t_(对照组)=11.224,均P=0.000)。治疗后2组间比较,观察组SⅠT长于对照组,差异有统计学意义(t=5.827,P=0.000)。(5)LTMH:2组治疗后LTMH均较治疗前升高,差异均有统计学意义(t_(观察组)=13.151、t_(对照组)=8.374,均P=0.000)。治疗后2组间比较,观察组LTMH高于对照组,差异有统计学意义(t=3.492,P=0.001)。(6)临床疗效:观察组总有效率高于对照组,差异有OBJECTIVE To observe the clinical efficacy of Houttuynia Cordata eye drops nebulization combined with meibomian gland massage in treating meibomian gland dysfunction(MGD)-related dry eye.METHODS A total of 160 patients(160 eyes)diagnosed with MGDrelated dry eye in Beijing Huairou Hospital of Traditional Chinese Medicine from January 2022 to December 2022 were included.They were randomly divided into a control group(CG)and an observation group(OG),with 80 cases(80 eyes)in each group,all of which were treated with the right eye.The control group received meibomian gland massage combined with 0.1%sodium hyaluronate eye drops.The observation group received Houttuynia Cordata eye drops nebulization in addition to the treatment in the control group.Both groups were treated for four weeks.Clinical symptom scores,ocular surface disease index(OSDI)scores,tear film breakup time(BUT),Schirmer I test(SⅠT),and lower tear meniscus height(LTMH)were measured before and after treatment.RESULTS There was no significant difference in clinical symptom scores,OSDI scores,BUT,SⅠT,and LTMH between the two groups before treatment(P>0.05).(1)Clinical symptom scores:After treatment,the clinical symptom scores in both groups were significantly reduced compared to before treatment,and the differences were statistically significant(t_(OG)=18.441,t_(CG)=9.932,both P=0.000).The clinical symptom scores in the observation group were lower than those in the control group after treatment,and the difference was statistically significant(t=2.315,P=0.022).(2)OSDI scores:After treatment,the OSDI scores in both groups were significantly reduced compared to before treatment,and the differences were statistically significant(t_(OG)=15.043,t_(CG)=16.841,both P=0.000).The OSDI scores in the observation group were lower than those in the control group after treatment,and the difference was statistically significant(t=3.240,P=0.001).(3)BUT:After treatment,the BUT in both groups was significantly increased compared to before treatment,and the difference w

关 键 词：鱼腥草滴眼液 睑板腺功能障碍 干眼 睑板腺按摩 

分 类 号：R276.7[医药卫生—中医五官科学]