成人支气管哮喘患者血清总IgE和过敏原特异性IgE检测结果分析  

An Analysis of Serum Total IgE and Allergen-specific IgE Test Results in Adult Patients with Bronchial Asthma

作　　者：王金英[1] 张子然 郑伟 WANG Jinying;ZHANG Ziran;ZHENG Wei(Department of Clinical Laboratory,Beijing Chaoyang Hospital Affiliated to Capital Medical University,Beijing 100043,China;Department of Clinical Medical Research,Beijing Chaoyang Hospital Affiliated to Capital Medical University,Beijing 100043,China)

机构地区：[1]首都医科大学附属北京朝阳医院检验科,北京100043 [2]首都医科大学附属北京朝阳医院临床医学研究室,北京100043

出　　处：《标记免疫分析与临床》2024年第5期794-798,839,共6页Labeled Immunoassays and Clinical Medicine

摘　　要：目的探讨成人支气管哮喘患者过敏原总免疫球蛋白E(tlgE)和特异性免疫球蛋白E(sIgE)的分布特征,以期为准确识别和区分过敏性哮喘患者提供帮助。方法选取2020年1月至2022年12月就诊于北京朝阳医院京西院区呼吸科临床诊断为支气管哮喘疾病的成人患者717例,应用德国西门子公司(Siemens)全自动特定蛋白仪BN II和瑞典Phadia AB公司Phadia 250全自动荧光酶联免疫分析系统分别检测患者血清tlgE和过敏原sIgE,对血清tlgE和sIgE检测结果进行回顾性分析。结果成人支气管哮喘患者tlgE和sIgE的总阳性率分别为50.5%和34.4%。室内过敏原比食物过敏原更常见。过敏原slgE阳性率前3位依次为户尘螨(d1)、霉菌和酵母组合2(mx2)和狗皮屑(e5);致敏重度率前3位的为e5、食物组合5(fx5)和d1。对于e5和mx2,男性sIgE阳性率明显高于女性(P<0.05),青年组明显高于老年组(P<0.05)。多重过敏患者占sIgE的阳性患者的66%,青年组和老年组较中年组更为常见。d1阳性样本中合并至少其他一种过敏原的患者占到87.1%。结论检测支气管哮喘患者血清tlgE和sIgE水平,有助于区分和鉴别过敏性哮喘。研究发现,在成人过敏原阳性患者中,d1、mx2、e5为最主要的吸入性过敏原。青年男性是更易致敏的人群;青年和老年群体通常会出现多重致敏的现象。Objective To explore the distribution characteristics of total IgE and allergen-specific IgE in adult bronchial asthma,and to further facilitate the accurate identification and differentiation of patients with allergic asthma.Methods A total of 717 adult patients with bronchial asthma who were admitted to the Respiratory Department of Beijing Chaoyang Hospital from January,2020 to December,2022 were selected for the study.Serum tlgE and allergen sIgE levels were detected by the automatic specific protein analyzer BN II(Siemens,Germany)and Phadia 250(Phadia AB,Sweden),respectively.The detected dataset was retrospectively analyzed to identify distribution of allergen sensitivity in different age and sex groups.Results The overall rates of tlgE and sIgE positivity were 50.5%and 34.4%,respectively.Indoor allergens were more common than food allergens.Among slgE,IgE specific for house dust mite(d1),mold and yeasts mix 2(mx2),and dog dander(e5)were the most common sources.Allergy was most severe for e5,food mix 5(fx5),and d1.sIgE positivity for e5 and mx2 was significantly higher in males than in females(P<0.05).Allergen sensitivity was significantly higher among the young-age group than in the elderly age group(P<0.05).Multiple allergies were present in 66%of slgE-positive patients and were more common in young-age adults and the elderly than in the middle-aged group.Approximately 87.1%of d1-positive patients had sensitivity to at least one other type of allergen.Conclusion Detection of serum tlgE and sIgE in patients with bronchial asthma can help differentiate and identify allergic asthma.Our research has showed that among adult allergen-positive patients,d1,mx2,and e5 are the most common inhalant allergens.Young males are more susceptible to sensitization,and multiple sensitizations are common in young and elderly people.

关 键 词：支气管哮喘 过敏原 总IGE 特异性IGE 成人 

分 类 号：R562.65[医药卫生—呼吸系统]