体液免疫与成人斯蒂尔病患者住院次数相关分析  

An Analysis of the Correlation Between Humoral Immunity and Hospitalization Times in Adults with Still’s Disease

作　　者：贾德天 王慧娟[2] JIA Detian;WANG Huijuan(Department of Respiratory Medicine,Beijing Renhe Hospital,Beijing 102600,China;Department of Respiratory and Critical Care Medicine,Beijing Chaoyang Hospital,Institute of Respiratory Medicine,Capital Medical University,Beijing 100016,China)

机构地区：[1]北京市仁和医院呼吸内科,北京102600 [2]首都医科大学附属北京呼吸医学研究所北京朝阳医院呼吸与危重症医学科,北京100016

出　　处：《标记免疫分析与临床》2024年第5期877-879,952,共4页Labeled Immunoassays and Clinical Medicine

摘　　要：目的探讨体液免疫水平与成人斯蒂尔病患者住院次数的相关性。方法根据住院次数将57例病情活动期斯蒂尔病患者分为两组,运用酶联免疫吸附试验(ELISA)来对血清免疫球蛋白、补体水平IgA、IgM、IgG等水平进行检测。结果57例AOSD患者被分为未再入院组(N=1,n=26)和再入院组(N>1,n=31)。N>1组的IgA水平低于N=1组。IgA水平与住院次数呈负相关,r=-0.436,P=0.002。结论血清IgA水平与斯蒂尔病患者住院次数呈负相关,血清IgA降低是成人斯蒂尔病复发相关的危险因素。Objective To investigate the correlation between humoral immune levels and the number of hospitalizations in adult Still’s disease patients.Methods 57 active stage adult-onset Still’s disease(AOSD)patients were divided into two groups based on the number of hospitalizations,and levels of immunoglobulin,complement,IgA,IgM,IgG were detected using enzyme-linked immunosorbent assay(ELISA).Results 57 AOSD patients were divided into a non-readmission group(N=1,n=26)and a readmission group(N>1,n=31).The IgA level in group N>1 was lower than group N=1.The IgA level was negatively correlated with the number of hospitalizations(r=-0.436,P=0.002).Conclusion The serum IgA level is negatively correlated with the number of hospitalizations,and reduced serum IgA is a risk factor for the recurrence of AOSD.

关 键 词：成人斯蒂尔病 免疫球蛋白A 补体 再住院 

分 类 号：R593.2[医药卫生—内科学]