洗涤红细胞在反复输注红细胞患者输血治疗中的应用效果  

The application effect of washed red blood cells in the transfusion therapy of patients with repeated red blood cell transfusion

作　　者：宋庆华 SONG Qing-hua(Blood Transfusion Department,Dandong First Hospital,Dandong 118000,China)

机构地区：[1]丹东市第一医院输血科,118000

出　　处：《中国现代药物应用》2024年第12期93-96,共4页Chinese Journal of Modern Drug Application

摘　　要：目的研究洗涤红细胞在反复输注红细胞患者输血治疗中的应用价值。方法138例需反复输注红细胞治疗的患者为研究对象,以随机数字表法分为对照组与观察组,各69例。对照组采用去白细胞悬浮红细胞输注,观察组采用洗涤红细胞输注。对比两组的输血不良反应发生率、实验室指标[血红蛋白(Hb)、红细胞计数(RBC)、网织红细胞比例(Rtc)、血小板计数(PLT)、白细胞计数(WBC)]及治疗效果。结果观察组患者的总有效率97.10%高于对照组的85.51%,差异显著(χ^(2)=5.841,P=0.016<0.05)。两组患者输血后的Hb、RBC均较输血前明显提高,Rtc较输血前明显降低,且观察组输血后的Hb(78.95±5.48)g/L、RBC(3.12±0.43)×10^(12)/L均高于对照组的(71.34±5.23)g/L、(2.75±0.39)×10^(12)/L,Rtc(18.54±1.23)%明显低于对照组的(23.43±1.58)%(P<0.05);观察组输血后的PLT和WBC比较差异均不显著(P>0.05)。观察组输血不良反应发生率为5.80%,对照组为8.70%,两组输血不良反应发生率比较差异不显著(χ^(2)=0.431,P=0.511>0.05)。结论洗涤红细胞在反复输注红细胞治疗的患者中应用效果肯定,能快速缓解患者的贫血症状,且安全性高,值得在临床进行推广。Objective To study the application value of washed red blood cells in the transfusion therapy of patients with repeated red blood cell transfusion.Methods 138 patients requiring repeated red blood cell infusion were studied and divided into a control group and an observation group by random number table method,with 69 patients in each group.The control group was transfused with leucocyte-reduced red blood cell suspension,and the observation group was transfused with washed red blood cells.Both groups were compared in terms of incidence of adverse transfusion reactions,laboratory indicators[hemoglobin(Hb),red blood cell count(RBC),reticulocyte ratio(Rtc),platelet count(PLT),white blood cell count(WBC)]and therapeutic effect.Results The total effective rate of the observation group was 97.10%,which was higher the control group's 85.51%,and the difference was significant(χ^(2)=5.841,P=0.016<0.05).After transfusion,Hb and RBC in both groups were significantly higher than those before transfusion,and Rtc was significantly lower than that before transfusion;the observation group had Hb of(78.95±5.48)g/L and RBC of(3.12±0.43)×10^(12)/L,which were higher than(71.34±5.23)g/L and(2.75±0.39)×10^(12)/L in the control group;the observation group had significantly lower Rtc of(18.54±1.23)%than(23.43±1.58)%in the control group(P<0.05).There were no significant differences in PLT and WBC after blood transfusion in the observation group(P>0.05).The incidence of adverse transfusion reactions was 5.80%in the observation group and 8.70%in the control group.There was no significant difference in the incidence of adverse transfusion reactions between the two groups(χ^(2)=0.431,P=0.511>0.05).Conclusion The application effect of washed red blood cells in patients with repeated red blood cell transfusion is certain,and it can quickly relieve the anemia symptoms of patients,and it is safe and worthy of clinical promotion.

关 键 词：反复输注红细胞 洗涤红细胞 去白细胞 不良反应 

分 类 号：R457.1[医药卫生—治疗学]