左氧氟沙星联合清肺化痰汤治疗慢性支气管炎患者的效果及对炎症指标的影响  

Effect of levofloxacin combined with Qingfei Huatan Decoction in the treatment of chronic bronchitis and its influence on inflammatory markers

作　　者：吴建国 WU Jian-guo(Xinshi Town Health Center of Jiyang District,Jinan 251403,China)

机构地区：[1]山东省济南市济阳区新市镇卫生院,251403

出　　处：《中国现代药物应用》2024年第12期156-159,共4页Chinese Journal of Modern Drug Application

摘　　要：目的观察左氧氟沙星联合清肺化痰汤治疗慢性支气管炎患者的效果及对炎症指标的影响。方法选取90例慢性支气管炎患者作为研究对象,根据患者个人意愿将其分成观察组和对照组,各45例。对照组采取左氧氟沙星治疗,观察组采取左氧氟沙星联合清肺化痰汤治疗。对比两组治疗前后中医证候积分、炎症指标[C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]、肺功能[用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、FEV1/FVC]、生活质量及临床效果。结果两组治疗后咳嗽、咳痰、舌尖红、苔薄黄、脉细数积分比本组治疗前更低,且观察组咳嗽、咳痰、舌尖红、苔薄黄、脉细数积分比对照组更低(P<0.05)。两组治疗后CRP、TNF-α、IL-6水平比本组治疗前更低,且观察组CRP(13.56±1.82)mg/L、TNF-α(1.13±0.20)ng/ml、IL-6(129.65±14.31)ng/L比对照组的(21.34±2.45)mg/L、(1.59±0.39)ng/ml、(163.80±15.64)ng/L更低(P<0.05)。两组治疗后FVC、FEV1、FEV1/FVC比本组治疗前更高,且观察组FVC(3.38±0.34)L、FEV1(2.38±0.30)L、FEV1/FVC(61.72±4.81)%比对照组的(2.85±0.26)L、(1.78±0.35)L、(56.76±4.20)%更高(P<0.05)。两组治疗后躯体不适、社会心理问题、功能状况、情感健康、极端躯体不适、自身安全担忧评分比本组治疗前更低,且观察组躯体不适、社会心理问题、功能状况、情感健康、极端躯体不适、自身安全担忧评分比对照组更低(P<0.05)。观察组治疗总有效率93.33%比对照组的73.33%更高(P<0.05)。结论左氧氟沙星联合清肺化痰汤能够提高慢性支气管炎患者的临床效果,改善患者临床症状,抑制炎症因子的释放,促进肺功能早日康复。Objective To observe the influence of levofloxacin combined with Qingfei Huatan Decoction on inflammatory markers and effects in patients with chronic bronchitis.Methods A total of 90 patients with chronic bronchitis were selected as the study subjects and divided into an observation group and a control group according to the patients'individual wishes,with 45 cases in each group.The control group was treated with levofloxacin,and the observation group was treated with levofloxacin combined with Qingfei Huatan Decoction.Comparison was made on traditional Chinese medicine syndrome score,inflammatory markers[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],lung function[forced vital capacity(FVC),forced expiratory volume in one second(FEV1),FEV1/FVC]and quality of life before and after treatment,and clinical effect.Results After treatment,the scores of cough,expectoration,red-tipped tongue,thin yellow fur and thready and rapid pulse in both groups were lower than those before treatment in this group,and the scores of cough,expectoration,red-tipped tongue,thin yellow fur and thready and rapid pulse in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of CRP,TNF-αand IL-6 in both groups were lower than those before treatment;the observation group had CRP of(13.56±1.82)mg/L,TNF-αof(1.13±0.20)ng/ml and IL-6 of(129.65±14.31)ng/L,which were lower than(21.34±2.45)mg/L,(1.59±0.39)ng/ml and(163.80±15.64)ng/L in the control group(P<0.05).After treatment,FVC,FEV1 and FEV1/FVC in both groups were higher than those before treatment in this group;the observation group had FVC of(3.38±0.34)L,FEV1 of(2.38±0.30)L and FEV1/FVC of(61.72±4.81)%,which were higher than(2.85±0.26)L,(1.78±0.35)L and(56.76±4.20)%in the control group(P<0.05).After treatment,the scores of physical discomfort,psychosocial problems,functional status,emotional health,extreme physical discomfort and self-safety concern in both groups were lower than those before treatmen

关 键 词：左氧氟沙星 清肺化痰汤 慢性支气管炎 炎症指标 肺功能 

分 类 号：R562.21[医药卫生—呼吸系统]