1例多种抗凝剂依赖致假性血小板减少伴白细胞吞噬血小板病例汇报  

Multi-anticoagulant-dependent Pseudothrombocytopenia with Platelet Phagocytosis by Leukocytes:a Case Report

作　　者：何逸琳 边春红 彭兴悦 张昊强 王荣祺[1] HE Yilin;BIAN Chunhong;PENG Xingyue;ZHANG Haoqiang;WANG Rongqi(Department of Clinical Laboratory,Beijing Haidian Hospital,Peking University Third Hospital,Beijing 100080,China)

机构地区：[1]北京市海淀医院,北京大学第三医院海淀院区检验科,北京100080

出　　处：《标记免疫分析与临床》2024年第6期1171-1176,共6页Labeled Immunoassays and Clinical Medicine

基　　金：北京市海淀区卫生健康发展科研培育计划(编号:HP2021-30-10102)。

摘　　要：假性血小板减少(pseudothrombocytopenia,PTCP),是一种仅发生在体外的实验室现象,患者本身无病理或生理性改变。抗凝剂依赖性假性血小板减少以EDTA-K 2(乙二胺四乙酸二钾-Edathamil)抗凝静脉血较为多见,也可见于枸橼酸钠、肝素抗凝静脉血。本病例出现多种抗凝剂依赖的假性血小板减少,同时伴中性粒细胞(neutrophil,N)卫星现象及中性粒细胞、淋巴细胞(lymphocyte,L)、单核细胞(monocytes,M)吞噬血小板(platelet,PLT)的情况。通过该病例的发现,提示我们要辩证地看待患者病情及辅助检查结果,切勿盲目下定论,否则可能会造成误诊或不必要的治疗。Pseudothrombocytopenia(PTCP)is a laboratory phenomenon that only occurs in vitro,and no pathological or physiological changes can be observed in patients.The common precipitating factors for PTCP include inductions with different types of anticoagulants,and infections in ethylenediaminetetraacetic acid dipotassium(EDTA-K 2)-Edathamil-anticoagulated venous blood.This study reported a case of multi-anticoagulant-dependent PTCP with platelet satellitism and phagocytosis by neutrophils,lymphocytes and monocytes.Through the study of this specific case,it is suggested that different manifestations of anticoagulant-dependent PTCP can be supplemented.The results of this case implies the necessity to approach the patient’s condition and auxiliary examination information dialectically,while not to make a blind conclusion,otherwise it may lead to a misdiagnosis or unnecessary treatment.

关 键 词：抗凝剂依赖 假性血小板减少 血小板 吞噬 显微镜镜检 

分 类 号：R446[医药卫生—诊断学]