非洲猪瘟病毒致病机制及防治策略研究进展  

Research Progress on the Pathogenic Mechanism and Prevention Strategy of African Swine Fever Virus

作　　者：王美乐 于扬帆 徐朋 陈青 安珂兰·安维尔 李姝璇 杨松华 尹素改[1,3] 冯书营 WANG Meile;YU Yangfan;XU Peng;CHEN Qing;AKILA·ANWAR;LI Shuxuan;YANG Songhua;YIN Sugai;FENG Shuying(Henan University of Chinese Medicine School of Medicine,Zhengzhou 450046,China;Puyang Medical College,Puyang 457000,China;Henan Engineering Research Center for Chinese Medicine Foods for Special Medical Purpose,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学医学院,郑州450046 [2]濮阳医学高等专科学校,濮阳457000 [3]河南省中医药特医食品工程研究中心,郑州450046

出　　处：《中国畜牧兽医》2024年第7期3041-3055,共15页China Animal Husbandry & Veterinary Medicine

基　　金：河南省科技攻关项目(212102110165);河南省高等学校重点研究计划项目(22B360015);河南省高校企业横向合作项目(20200011);河南省高等学校重点科研项目计划(23A180014)。

摘　　要：非洲猪瘟(African swine fever,ASF)是一种急性、出血性、高度接触性的烈性传染病,对世界养猪业和食品安全产生了巨大的负面影响,目前仍无商品化疫苗和特效药物。其病原体非洲猪瘟病毒(African swine fever virus,ASFV)是一种大型、结构复杂的双链DNA病毒,但80%的编码蛋白功能未知,因此其致病机制及药物研究现状对防控具有重要意义。作者概述了ASFV的病原体特征、传播途径及其引起的临床表现;从病毒入侵过程、免疫细胞功能改变及其相关通路变化等方面梳理了病毒致病机制的最新进展;介绍了ASFV的最新检测技术及疫苗新进展;系统总结了最新的中西药治疗研究现状,并对中药防治ASFV的未来前景进行展望,提出了未来重点研究方向和相关问题解决策略,以期为ASF的治疗提供借鉴和指导。African swine fever(ASF)is an acute,hemorrhagic and highly contagious disease,which has a huge negative impact on the world pig industry and food security.There are still no specific drugs and vaccines for the prevention and treatment.African swine fever virus(ASFV)is a large,complex double-stranded DNA virus,but the function of 80%of the encoded proteins is unknown.Therefore,its pathogenic mechanism and drug research status are of great significance for prevention and control.The author summarized the pathogen characteristics,transmission routes and clinical manifestations of ASFV.The latest progress of viral pathogenesis was reviewed from the aspects of virus invasion process,immune cell function changes and related pathway changes.The latest detection technology and vaccine progress of ASFV were introduced.This paper systematically summarized the latest research status of Chinese and Western medicine treatment,the future prospects of traditional Chinese medicine in the prevention and treatment of ASFV were prospected,and the key research directions and related problem solving strategies in the future were put forward,in order to provide reference and practical guidance for the treatment of ASF.

关 键 词：非洲猪瘟病毒(ASFV) 致病机制 预防措施 中药 

分 类 号：S855.3[农业科学—临床兽医学]