猪源病毒细胞毒性T淋巴细胞表位研究进展  

Advances in Cytotoxic T Lymphocyte Epitopes of Porcine Viruses

作　　者：鲜钰涵 冯宏盛 高永宇 李海洋 杨思宇 桑辰君 曹玉蝶 唐越 李子彬 高凤山[1,3] XIAN Yuhan;FENG Hongsheng;GAO Yongyu;LI Haiyang;YANG Siyu;SANG Chenjun;CAO Yudie;TANG Yue;LI Zibin;GAO Fengshan(College of Life and Health,Dalian University,Dalian 116622,China;College of Animal Medicine,Jilin Agriculture University,Changchun 130118,China;The Dalian Animal Virus Antigen Epitope Screening and Protein Engineering Drug Developing Key Laboratory,Dalian 116622,China)

机构地区：[1]大连大学生命健康学院,大连116622 [2]吉林农业大学动物医学院,长春130118 [3]大连市动物病毒抗原表位筛选及蛋白质工程药物研发重点实验室,大连116622

出　　处：《中国畜牧兽医》2024年第7期3086-3099,共14页China Animal Husbandry & Veterinary Medicine

基　　金：国家自然科学基金项目(32273022);大连大学创新团队项目(202011015)。

摘　　要：主要组织相容性复合体(major histocompatibility complex,MHC)Ⅰ类分子,也称为猪白细胞抗原(swine leukocyte antigen,SLA)Ⅰ类分子,在机体抗原递呈、器官移植、细胞免疫应答和调控等方面起重要作用。细胞毒性T淋巴细胞(cytotoxic T lymphocyte,CTL)表位是抗原经抗原递呈细胞加工后,与SLA-Ⅰ类分子结合并递呈的线性肽段,具有高度特异性,在机体抗原识别递呈和细胞免疫抵抗病毒感染方面发挥着关键作用。CTL表位能够刺激CTLs发挥细胞杀伤作用,主要表现为杀伤病毒。作者将对口蹄疫病毒、非洲猪瘟病毒和猪繁殖与呼吸综合征病毒等几种重要的猪源病毒的CTL表位研究现状进行综述,并利用生物信息学手段分析SLA-Ⅰ与CTL表位结合基序特征,以期为今后相关猪源病毒CTL表位的研究和多表位疫苗的设计提供参考。The major histocompatibility complex(MHC)classⅠmolecules,also known as swine leukocyte antigen(SLA)classⅠmolecules,play an important role in antigen presentation,organ transplantation,immune response and regulation.Cytotoxic T lymphocyte(CTL)epitopes are linear peptides that bind and present SLA-Ⅰmolecules after antigen processing by antigen-presenting cells.With high specificity,CTL epitopes play a key role in antigen recognition and presentation and cellular immunity against viral infection.CTL epitopes can stimulate CTLs to play the role of cell killing,which is mainly manifested as killing virus.The author reviewed the current status of CTL epitopes of several important porcine viruses,such as Foot-and-mouth disease virus,African swine fever virus and Porcine reproductive and respiratory syndrome virus,and analyzed the binding motif characteristics of SLA-Ⅰand CTL epitopes by bioinformatics,in order to provide a reference for studying CTL epitopes derived from porcine viruses and designing the epitope vaccine in future.

关 键 词：细胞毒性T淋巴细胞(CTL)表位 猪口蹄疫病毒 非洲猪瘟病毒 猪繁殖与呼吸综合征病毒 

分 类 号：S852.4[农业科学—基础兽医学]