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作 者:胡瑶 刘玲[1] Hu Yao;Liu Ling(Department of Urinary Nephropathy Center,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 401336,China)
机构地区:[1]重庆医科大学附属第二医院泌尿肾病中心,重庆401336
出 处:《器官移植》2024年第4期648-652,共5页Organ Transplantation
基 金:国家自然科学基金(81873881)。
摘 要:镁作为细胞内含量丰富且具有广泛作用的阳离子,在免疫功能方面发挥着积极的作用,备受关注。在多种因素的影响下,如使用钙调磷酸酶抑制剂等,肾移植术后低镁血症的发生并不罕见。感染是肾移植术后常见的并发症,也是导致肾移植受者死亡的常见原因之一。近年来的临床研究表明,肾移植术后低镁血症与移植后感染风险密切相关。在肾移植受者中关注并监测镁浓度可能有助于预防感染的发生,改善受者及移植物预后。因此,本文就镁与免疫反应、肾移植术后低镁血症发生的原因及肾移植术后低镁血症与感染的相关研究进展进行综述,以期为肾移植术后感染的预防与治疗提供参考。As a cation with abundant intracellular contents and extensive functions,magnesium plays an active role in immune function and captivates widespread attention.Under the influence of multiple factors,such as use of calcineurin inhibitors,hypomagnesemia post-kidney transplantation is not uncommon.Infection is a common complication post-kidney transplantation and one of the main causes of death of kidney transplant recipients.Recent clinical studies have shown that hypomagnesemia post-kidney transplantation is closely associated with the risk of infection posttransplantation.Emphasizing and monitoring magnesium concentration in kidney transplant recipients may help prevent infection and improve clinical prognosis of both recipients and grafts.Therefore,research progress in magnesium and immune response,the causes of hypomagnesemia post-kidney transplantation and hypomagnesemia and infection postkidney transplantation was reviewed,aiming to provide reference for the prevention and treatment of infection post-kidney transplantation.
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