住院患儿静脉用药不良反应的分析  

Analysis of Adverse Drug Reactions of Intravenous Medication in Hospitalized Children

作　　者：申键 靳蓉 祁巧芳 SHEN Jian;JIN Rong;QI Qiaofang(Department of Pharmacy,Luoyang Maternal and Child Health Hospital,Luoyang Henan 471000,China)

机构地区：[1]洛阳市妇幼保健院药学部,河南洛阳471000

出　　处：《临床研究》2024年第7期38-41,共4页Clinical Research

摘　　要：目的了解洛阳市妇幼保健院住院患儿静脉用药不良反应发生情况,分析不良反应发生特点并提出相应对策,以便提升患儿静脉用药安全性。方法回顾性分析洛阳市妇幼保健院2022年6月年2023年6月接收的87例住院患儿的药物不良反应(ADR)报告,所有患儿均接受过静脉用药治疗,统计患儿的年龄、性别、原发病、药物类型、ADR发生时间、ADR累及器官和(或)系统、临床表现及转归情况。结果87例住院患儿中,男患儿占67.82%,女患儿占32.18%,男性多于女性,差异有统计学意义(χ^(2)=22.092,P<0.05);<1岁患儿占比高于其他年龄段,差异有统计学意义(χ^(2)=30.456,P<0.05)。患儿原发病主要为呼吸系统疾病、消化系统疾病、血液系统疾病等;静脉用药类型主要为抗感染药物、呼吸系统药物、激素类药物、循环系统药物等,呼吸系统疾病所占比例高于其他疾病,抗感染药物所占比例高于其他类型药物,差异均有统计学意义(χ^(2)=25.674、58.752,均P<0.05)。用药1~72 h ADR发生率高于1 h内与72 h后,差异有统计学意义(χ^(2)=41.379,P<0.05)。ADR累及皮肤及附件、消化系统、循环系统、呼吸系统等多个器官及系统,其中,皮肤及附件与消化系统ADR发生率高于其他系统,差异有统计学意义(χ^(2)=102.704,P<0.05)。结论本院住院儿童静脉用药ADR与多种因素均存在一定联系,累计器官或系统多样,临床需继续加强对住院患儿静脉治疗期间的药学管理,提高用药合理性,进而预防ADR的发生。Objective To understand the occurrence of adverse drug reaction(ADR)of intravenous medication in hospitalized children in Luoyang Maternal and Child Health Hospital,analyze the characteristics of ADRs,and propose corresponding strategies to improve the safety of intravenous medication in children.Methods A retrospective analysis was conducted on the ADR reports of 87 hospitalized children received in Luoyang Maternal and Child Health Hospital from June 2022 to June 2023.All children had received intravenous medication treatment.The age,gender,primary disease,drug type,ADR occurrence time,organs and(or)systems involved in ADR,clinical manifestations,and outcomes of the children were statistically analyzed.Results Among the 87 hospitalized children,67.82%were male and 32.18%were female,with males being more than females,with a statistically significant difference(χ^(2)=22.092,P<0.05).Children under 1 year old accounted for a higher proportion than other age groups,with a statistically significant difference(χ^(2)=30.456,P<0.05).The primary diseases of the children were mainly respiratory system diseases,digestive system diseases,blood system diseases,etc.The types of intravenous medication were mainly anti-infective drugs,respiratory system drugs,hormone drugs,circulatory system drugs,etc.The proportion of respiratory system diseases was higher than other diseases,and the proportion of anti-infective drugs was higher than other types of drugs,with statistically significant differences(χ^(2)=25.674,58.752,both P<0.05).The ADR occurrence rate of medication from 1 to 72 hours was higher than within 1 hour and after 72 hours,with a statistically significant difference(χ^(2)=41.379,P<0.05).ADR involved multiple organs and systems such as skin and appendages,digestive system,circulatory system,respiratory system,etc.Among them,the ADR occurrence rate of skin and appendages and digestive system was higher than other systems,with a statistically significant difference(χ^(2)=102.704,P<0.05).Conclusion The ADR of intrav

关 键 词：住院儿童 静脉用药 药物不良反应 药物类型 累及器官 临床表现 

分 类 号：R452[医药卫生—治疗学]