血清甲状旁腺激素与血清胱抑素C的水平变化在肾衰尿毒症患者诊断中的应用研究  

Application Study of Serum Parathyroid Hormone and Serum Cystatin C Level Changes in the Diagnosis of Renal Failure Uremia Patients

作　　者：杨林清 项雪莹 束欢欢 YANG Linqing;XIANG Xueying;SHU Huanhuan(Department of Laboratory Medicine,Luoyang West City Hospital,Luoyang Henan 471000,China)

机构地区：[1]洛阳西城医院检验科,河南洛阳471000

出　　处：《临床研究》2024年第7期125-127,共3页Clinical Research

摘　　要：目的探究血清甲状旁腺激素(PTH)与血清胱抑素C(Cys-C)的水平变化在肾衰尿毒症患者诊断中的应用价值。方法在洛阳西城医院选取20例肾衰尿毒症患者作为实验组研究对象,选取20例慢性肾衰患者作为对照A组研究对象;另外选取24例参与健康体检的健康者作为对照B组研究对象。选取时间:2021年1月至2023年10月。对比三组血清PTH、Cys-C检测水平,利用Pearson相关分析确定PTH、Cys-C与肾衰尿毒症发生的相关性;将肾功能检查作为金标准,计算联合检查诊断准确率。结果实验组PTH、Cys-C检测水平明显高于对照A组、对照B组,差异有统计学意义(P<0.05);PTH、Cys-C检测值越高则肾衰尿毒症发生风险越高,成正相关(P<0.05);PTH单项检查检出例数为14例(占比为70.00%),Cys-C单项检查检出例数为15例(占比为75.00%),联合检查检出例数为20例(占比为100.00%),联合检查诊断准确率高于单项检查,差异有统计学意义(P<0.05)。结论PTH、Cys-C可作为肾衰尿毒症的诊断指标,PTH、Cys-C检测值越高则肾衰尿毒症发生风险越高,在临床诊疗过程中可以此做出基础判断,进而确定最佳治疗方案,值得应用。Objective To explore the application value of serum parathyroid hormone(PTH)and serum cystatin C(Cys-C)level changes in the diagnosis of renal failure uremia patients.Methods Twenty cases of renal failure uremia patients treated in Luoyang West City Hospital from January 2021 to October 2023 were selected as the experimental group,and 20 cases of chronic renal failure patients were selected as the control A group.In addition,24 healthy individuals who participated in health examinations were selected as the control B group.The serum PTH and Cys-C levels of the three groups were compared,and Pearson correlation analysis was used to determine the correlation between PTH and Cys-C and the occurrence of renal failure uremia.Renal function examination was used as the gold standard to calculate the diagnostic accuracy of combined examination.Results The levels of PTH and Cys-C in the experimental group were significantly higher than those in the control A group and the control B group,with statistically significant differences(P<0.05).The higher the detection values of PTH and Cys-C,the higher the risk of renal failure uremia,showing a positive correlation(P<0.05).The number of cases detected by single PTH examination was 14(accounting for 70.00%),and the number of cases detected by single Cys-C examination was 15(accounting for 75.00%).The number of cases detected by combined examination was 20(accounting for 100.00%).The diagnostic accuracy of combined examination was higher than that of single examination,with statistically significant differences(P<0.05).Conclusion PTH and Cys-C can be used as diagnostic indicators for renal failure uremia.The higher the detection values of PTH and Cys-C,the higher the risk of renal failure uremia.In the clinical diagnosis and treatment process,this can be used to make a basic judgment,and then determine the best treatment plan,which is worth applying.

关 键 词：甲状旁腺激素 血清胱抑素C 肾衰尿毒症 慢性肾衰 

分 类 号：R692[医药卫生—泌尿科学]