两个丁二肟有机锡配合物的合成、结构及抗癌活性  

Synthesis,structure,and anticancer activity of two complexes of dimethylglyoxime organotin

作　　者：卿菁菁 何帆 刘智辉 侯帅鹏 刘娅 蒋一凡 谭梦婷 何丽芳 张复兴 朱小明 QING Jingjing;HE Fan;LIU Zhihui;HOU Shuaipeng;LIU Ya;JIANG Yifan;TAN Mengting;HE Lifang;ZHANG Fuxing;ZHU Xiaoming(Hunan Provincial Key Laboratory of Functional Metal-Organic Compounds,Key Laboratory of Organometallic New Materials,College of Hunan Province,Hunan Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of Xiangjiang River,Department of Chemistry and Material Science,Hengyang Normal University,Hengyang,Hunan 421008,China)

机构地区：[1]衡阳师范学院化学与材料科学学院,功能金属有机化合物湖南省重点实验室,金属有机新材料湖南省普通高等学校重点实验室,湘江上游重金属污染监测与治理湖南省工程研究中心,衡阳421008

出　　处：《无机化学学报》2024年第7期1301-1308,共8页Chinese Journal of Inorganic Chemistry

基　　金：湖南省教育厅优秀青年项目(No.23B0669);湘江上游重金属污染监测与治理湖南省工程研究中心开放基金项目(No.2023HSKFJJ011);湖南省应用特色学科基金;湖南省高校科技创新团队支持计划;国家、湖南省和衡阳师范学院大学生创新创业训练计划项目资助。

摘　　要：合成了2个丁二酮肟有机锡化合物:双(三(2-甲基-2-苯基丙基)锡)丁二酮肟配合物(C_(6)H_(5)C(CH_(3))_(2)CH_(2))_(3)Sn(ON=C(CH_(3))C(CH_(3))=NO)Sn(CH_(2)C(CH_(3))_(2)C_(6)H_(5))_(3)(1)和二苄基锡氧氯丁二酮肟多核配合物[μ_(3)-O-((C_(6)H_(5)CH_(2))_(2)Sn)_(2)(ON=C(CH_(3))C(CH_(3))=NOH)(O)Cl]_(2)(2)。通过元素分析、红外光谱、核磁共振(^(1)H、^(13)C、^(119)Sn)、差热分析和单晶X射线衍射对配合物进行了结构表征,对其结构进行量子化学从头计算,并进行了体外抗癌活性研究。结果显示:配合物1为通过配体丁二酮肟桥联的双锡核中心对称分子,锡原子均为四配位的畸变四面体构型;配合物2为通过氧原子和丁二酮肟配体桥联的四锡核中心对称多环聚合结构,锡原子分别为五配位的畸变三角双锥构型和六配位的畸变八面体构型。配合物对人肝癌细胞(HUH7)、人肺癌细胞(A549)、人表皮癌细胞(A431)、人结肠癌细胞(HCT-116)和人乳腺癌细胞(MDA-MB-231)均有较强的抑制活性。Two dimethylglyoxime organotin compounds,bis(tri(2-methyl-2-phenylpropyl)tin) dimethylglyoxime complex(C_(6)H_(5)C(CH_(3))_(2)CH_(2))_(3)Sn(ON=C(CH_(3))C(CH_(3))=NO)Sn(CH_(2)C(CH_(3))_(2)C_(6)H_(5))_(3)(1) and di(benzyl)tin oxide,chlorine,butanedione oxime multinuclear complex [μ_(3)-O-((C_(6)H_(5)CH_(2))_(2)Sn)_(2)(ON=C(CH_(3))C(CH_(3))=NOH)(O)Cl]_(2)(2),were synthesized.The compounds were characterized by elemental analysis,IR spectroscopy,NMR(~1H,^(13)C,and ^(119)Sn),thermogravimetric analysis,and single-crystal X-ray diffraction,and quantum chemical ab initio calculation was performed for their structure and in vitro anticancer activity were studied for the compounds.The results showed that complex 1 is a central symmetric molecule with double tin nuclei bridged by the ligand dimethylglyoxime,and the tin atoms are distorted tetrahedral configurations with four coordination.Complex 2 is a central symmetric polycyclic polymerization structure of tetra-tin nuclei bridged by oxygen atoms and dimethylglyoxime,and the tin atoms are five-coordinated distorted triangular bipyramidal configuration and six-coordinated distorted octahedral configuration,respectively.In addition,the complexes have stronger inhibitory activity on human liver cancer cells(HUH7),human lung cancer cells(A549),human epidermal cancer cells(A431),human colon cancer cells(HCT-116),and breast cancer cells(MDA-MB-231).CCDC:2234708,1;2234707,2.

关 键 词：双(三(2-甲基-2-苯基丙基)锡)丁二酮肟配合物 二苄基锡氧氯丁二酮肟多核配合物 晶体结构 从头计算 体外抗肿瘤活性 

分 类 号：O614.432[理学—无机化学]