葡萄球菌性烫伤样皮肤综合征的研究进展  

Research progress of staphylococcal scaled skin syndrome

作　　者：张睿 尤聪 李龙年 叶小英 ZHANG Rui;YOU Cong;LI Long-nian;YE Xiao-ying(The First Clinical Medical School of Gannan Medical University;Department of Dermatology and Venereology,Candidate Branch of National Clinical Research Centre for Skin and Immune Diseases,The First Affiliated Hospital of Gannan Medical University,Ganzhou,Jiangxi 341000)

机构地区：[1]赣南医科大学第一临床医学院 [2]赣南医科大学第一附属医院皮肤性病科国家皮肤与免疫性疾病临床研究中心分中心建设单位,江西赣州341000

出　　处：《赣南医学院学报》2024年第6期617-621,共5页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：国家自然科学基金地区科学基金项目(81960566)。

摘　　要：葡萄球菌性烫伤样皮肤综合征(Staphylococcal scaled skin syndrome,SSSS)是一种潜在的、危及生命的急性表皮剥脱综合征。本病主要是由凝固酶阳性第Ⅱ组噬菌体金黄色葡萄球菌感染引起的皮肤病。SSSS的诊断主要根据临床表现,包括全身泛发性红斑、松弛性大疱、烫伤样表皮剥脱、口周放射性皲裂、尼氏征阳性以及黏膜不受累及。目前SSSS的治疗主要以抗金黄色葡萄球菌的抗生素为主,包括耐青霉素酶青霉素类、头孢菌素类、万古霉素、克林霉素等。近年来SSSS发病率以及发生并发症和死亡的风险在不断增加,本文对近年来有关SSSS的研究进展进行综述,以期为提高医务工作者对SSSS的认知和诊疗能力提供参考。Staphylococcal scaled skin syndrome(SSSS)is a potentially life-threatening disorder and an acute epidermal exfoliation syndrome.The disease is caused by toxigenic strains of Staphylococcus aureus(S.aureus)which belongs to phage groupⅡand produces soluble toxin-exfoliative toxins.The diagnosis is mainly based on clinical manifestations,including erythroderma,bullae,desquamation with a scalded appearance,perioral crusting,positive Niskolsky sign,and absence of mucosal involvement.At present,the anti-S.aureus antibiotics are used for treatment of SSSS,including penicillinase-resistant penicillin,cephalosporin,vancomycin,clindamycin and other antibiotics.Both the incidence and the risk of complications and death of SSSS are increasing year by year.The research progress on SSSS in recent years is summarized in the present review to improve the knowledge of healthcare workers on SSSS.

关 键 词：葡萄球菌性烫伤样皮肤综合征 金黄色葡萄球菌 剥脱毒素 抗生素 治疗 

分 类 号：R751[医药卫生—皮肤病学与性病学]