心血管纳米医学在血管平滑肌细胞中的应用  

Application of Cardiovascular Nanomedicine in Vascular Smooth Muscle Cells

作　　者：余玉庄 何宛欣 徐紫薇 陈金燕 郭颖欣 李华琴 YU Yuzhuang;HE Wanxin;XU Ziwei;CHEN Jinyan;GUO Yingxin;LI Huaqin(College of Healthy,Guangzhou Xinhua College,Guangzhou 510520,Guangdong,China)

机构地区：[1]广州新华学院健康学院,中国广东广州510520

出　　处：《生命科学研究》2024年第3期215-222,共8页Life Science Research

基　　金：广东省大学生创新训练项目(基于高血压模型挖掘调控血管平滑肌细胞转换的候选基因和miRNAs)(S202113902016)。

摘　　要：血管平滑肌细胞(vascular smooth muscle cell, VSMC)具有调节血管紧张性和维持血管形态的功能,其功能障碍与心血管疾病的发生、发展密切相关。纳米医学(nanomedicine)是指纳米材料在医学中的应用,因其能够克服传统治疗方式存在的药理学局限,如药物选择性差、生物利用度低等问题,被广泛应用于心血管疾病、肿瘤等的诊断和治疗。本文基于VSMC在心血管系统的关键作用和纳米医学在传统给药系统中的优化作用,概述了VSMC表型转换异常、恶性增殖和迁移引发心血管疾病的病理机制,总结了靶向改善VSMC功能来治疗心血管疾病的纳米应用,如靶向药物递送、自身靶向干预和组织工程支架制备等,最后讨论了心血管纳米医学面临的挑战和未来发展的方向,以期为预防和治疗心血管疾病提供潜在方案。Vascular smooth muscle cells(VSMCs)have the function of regulating vascular tension and maintaining vascular architecture,and their dysfunction is closely related to the onset and progression of cardiovascular maladies.Nanomedicine refers to the application of nanomaterials in medical sciences,which is widely used in the diagnosis and treatment of cardiovascular diseases,tumors and other diseases due to its ability to overcome the pharmacological impediments in conventional treatment modalities,such as poor drug selectivity and low bioavailability.Based on the key roles of VSMCs in the cardiovascular system and the optimization potential of nanomedicine in the traditional drug delivery systems,this paper reviewed the pathological mechanisms of cardiovascular diseases caused by anomalous phenotypic alterations,malignant proliferation and migration of VSMCs,and summarized the utility of nanomedicine in targeting VSMC functions as a therapeutic strategy against cardiovascular disorders,such as targeted drug delivery,autologous therapeutic interventions,and the fabrication of tissue engineering scaffolds.The paper also discussed the imminent challenges and future trajectories of cardiovascular nanomedicine,aiming to provide potential strategies for the prevention and treatment of cardiovascular diseases.

关 键 词：血管平滑肌细胞(VSMC) 心血管疾病 纳米医学 高血压 纳米材料 

分 类 号：Q25[生物学—细胞生物学] Q819[医药卫生—人体解剖和组织胚胎学] R329.2[医药卫生—基础医学]